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© Jean-Claude Antoine
Leishmania mexicana amazonensis
Publication : Cytokine

Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cytokine - 12 Mar 2016

Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Späth GF, Meng G

Link to Pubmed [PMID] – 26978550

Cytokine 2016 May;81:101-8

Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation which can be detected via various immunological methods such as enzyme linked immunosorbent assay (ELISA) and immunoblotting. In the current study, we found that a number of clinical isolates as well as laboratory strains of S. aureus exhibited cross reactivity with ELISA antibodies for murine IL-1β and TNF-α assays. This cross reactivity generates exaggerated false positive signals which can be a source of discrepancy for the understanding of real immune responses against S. aureus infection by host immune cells.

https://www.ncbi.nlm.nih.gov/pubmed/26978550