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Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Sylvie Pochet (PI)
Nucleoside analogues as potential antitumor agents. This project aims to characterize and validate the nucleotide N-hydrolase DNPH1 as a new target in oncology. Inhibition of Rcl alone or in combination with other chemotherapeutic drugs […]
2021The CovR regulatory network drives the evolution of Group B Streptococcus virulence., PLoS Genet 2021 Sep; 17(9): e1009761.
2021Characterization of a triad of genes in cyanophage S-2L sufficient to replace adenine by 2-aminoadenine in bacterial DNA., Nat Commun 2021 08; 12(1): 4710.
2021A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes., Science 2021 04; 372(6541): 516-520.
2021Noncanonical DNA polymerization by aminoadenine-based siphoviruses., Science 2021 04; 372(6541): 520-524.
2021How cyanophage S-2L rejects adenine and incorporates 2-aminoadenine to saturate hydrogen bonding in its DNA., Nat Commun 2021 04; 12(1): 2420.
2018Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus, PLoS Genet. 2018 Apr;14(4):e1007342.
2017Cyclic di-AMP in host-pathogen interactions, Curr. Opin. Microbiol. 2018 Feb;41:21-28.
2017Insights into the structure and assembly of a bacterial cellulose secretion system, Nat Commun 2017 Dec;8(1):2065.
2016Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production, Cell Host Microbe 2016 Jul;20(1):49-59.
2016PbsP, a cell wall-anchored protein that binds plasminogen to promote hematogenous dissemination of group B Streptococcus, Mol. Microbiol. 2016 Jul;101(1):27-41.
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