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Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Sylvie Pochet (PI)
Nucleoside analogues as potential antitumor agents. This project aims to characterize and validate the nucleotide N-hydrolase DNPH1 as a new target in oncology. Inhibition of Rcl alone or in combination with other chemotherapeutic drugs […]
2018Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus, PLoS Genet. 2018 Apr;14(4):e1007342.
2017Cyclic di-AMP in host-pathogen interactions, Curr. Opin. Microbiol. 2018 Feb;41:21-28.
2017Insights into the structure and assembly of a bacterial cellulose secretion system, Nat Commun 2017 Dec;8(1):2065.
2016Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production, Cell Host Microbe 2016 Jul;20(1):49-59.
2016PbsP, a cell wall-anchored protein that binds plasminogen to promote hematogenous dissemination of group B Streptococcus, Mol. Microbiol. 2016 Jul;101(1):27-41.
20146-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
2014Extracellular nucleotide catabolism by the Group B Streptococcus ectonucleotidase NudP increases bacterial survival in blood, J. Biol. Chem. 2014 Feb;289(9):5479-89.
2013N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1, PLoS ONE 2013;8(11):e80755.
2013Reversal of the substrate specificity of CMP N-glycosidase to dCMP, Biochemistry 2013 Jun;52(23):4037-47.
2013Structure of the oncoprotein Rcl bound to three nucleotide analogues, Acta Crystallogr. D Biol. Crystallogr. 2013 Feb;69(Pt 2):247-55.
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