The UMR3525 studies several aspects of genome biology, with a focus on maintenance and evolution of genetic information. On one hand, most teams work on the organisation, expression, and replication of genomes. On the other hand, most teams study how genomes change through time by mutations, gene acquisition, DNA loss and genetic rearrangements. The key biological models are enterobacteria, Vibrio, and yeast. Recently, the developments in our labs and the integration of the Berthelot team spurred development of projects in humans (and other mammals).
Click to view graph
Connections
Members
Groups
Laboratory

Dynamics of the Genome

Benoit Arcangioli
Laboratory

Bacterial Genome Plasticity

Didier Mazel
Laboratory

Microbial Evolutionary Genomics

Eduardo Rocha
Laboratory

Spatial Regulation of Genomes

Romain Koszul
Laboratory
UMR
G5

Comparative Functional Genomics

Camille Berthelot
Group

Group: Guy-Franck Richard

Guy-Franck Richard
Group

Cytoplasmic mRNA surveillance in yeast

Micheline Fromont-Racine
Former Members
Former directors of the UMR3525 or URA2171:
- Alain Jacquier (2012-2022)
- Bernard Dujon (2000-2011)
Former principal investigators of the UMR3525 or URA2171:
- Alain Jacquier (Genetics of molecular interactions)
- Bernard Dujon (Molecular genetics of yeast, retired)
- Antoine Danchin (Genetics of bacterial genomes, retired)
- Massimo Vergassola (Physics of the biological systems)
- Frank Kunst (Bacterial genomics, deceased)
- Carmen Buchrieser (Biology of intracellular bacteria)
- Philippe Glaser (Ecology and Evolution of Antibiotics Resistance)
- Roland Brosch (Integrated Mycobacterial Pathogenomics)
Software
Fundings
Publications
Download-
2023Chromosome folding and prophage activation reveal specific genomic architecture for intestinal bacteria., Microbiome 2023 May; 11(1): 111.
-
2023Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies., Elife 2023 Mar; 12(): .
-
2023Identification and characterization of thousands of bacteriophage satellites across bacteria., Nucleic Acids Res 2023 Mar; (): .
-
2023Chromosomal Position of Ribosomal Protein Genes Affects Long-Term Evolution of Vibrio cholerae., mBio 2023 Mar; (): e0343222.
-
2023Increasing the Scalability of Toxin-Intein Orthogonal Combinations., ACS Synth Biol 2023 Jan; (): .
-
2022Time-resolved microfluidics unravels individual cellular fates during double-strand break repair., BMC Biol 2022 Dec; 20(1): 269.
-
2022Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation., Nucleic Acids Res 2022 Nov; (): .
-
2021Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations., Nucleic Acids Res 2021 08; 49(14): 8120-8134.
-
+View full list of publications