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  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
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  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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© Melanie Blokesch, EPFL
Flagellated Vibrio cholerae
Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Oct 2019
Ending Date
30
Nov 2022
Status
Ongoing
Members
4
Structures
2

About

The RepliChroms project aims at decrypting plasmid adaptation mechanisms in their bacterial host. Bacterial genomes are composed of two types of replicons: chromosomes and plasmids. Bacteria commonly have a unique circular chromosome, and current models of genome dynamics are based on this assumption. However, 5-10% of bacteria also have secondary chromosomes which originate from megaplasmids. Secondary chromosomes and megaplasmids also called “chromids” confer specific traits to their host (e.g. pathogenicity, resistance). Incoming plasmids are often poorly adapted to their new hosts and their stabilization requires integration with the host’s cellular mechanisms in a process termed domestication. RepliChroms project focuses on the identification of the fundamental mechanisms driving chromid domestication in bacteria with a detailed description of their replication process.

Fundings