Timeline

Philippe Bousso

Head of Structure

01 Apr 2024

publication

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

25 Mar 2024

news

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

01 Sep 2023

publication

A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy

01 Jul 2023

publication

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

05 Jun 2023

news

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

17 May 2023

event

Pasteur International Cancer Conference 2023

17 Feb 2023

publication

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

29 Aug 2022

news

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

23 Aug 2022

publication

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

23 Aug 2022

publication

Inflammation triggers ILC3 patrolling of the intestinal barrier.

19 Jul 2022

publication

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

03 Jun 2022

news

New publication – High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing, Nature Communications, June 3, 2022

03 Jun 2022

publication

High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing.

14 Jun 2021

publication

Quorum sensing governs collective dendritic cell activation in vivo.

15 Apr 2021

publication

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

02 Apr 2021

news

Cancer: CAR T cell function scrutinized to improve immunotherapy

26 Mar 2021

publication

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

15 Mar 2021

news

Save the date: 20–22 October 2021 Meeting of Institut Pasteur and CIML

19 Feb 2021

news

Improving immunotherapies for blood cancers: real-time exploration in the tumor

01 Feb 2021

publication

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

09 Mar 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

01 Mar 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

04 Apr 2019

event

Department of Immunology seminar: Andrew Oberst, Too important to die: New antiviral roles for “cell death” pathways in the brain

14 Feb 2019

team

U1223 – Pathophysiology of the immune system

23 Nov 2018

publication

The immune system profoundly restricts intratumor genetic heterogeneity

19 Sep 2018

publication

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

01 Aug 2018

publication

A human immune system mouse model with robust lymph node development.

04 Jun 2018

event

Development and function of dendritic cell subsets

07 May 2018

project

ERC 2017-Advanced Grant ENLIGTHEN

27 Mar 2018

publication

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

01 Jan 2017

publication

Microchannels for the Study of T Cell Immunological Synapses and Kinapses

01 Jan 2017

publication

In Vivo Imaging of T Cell Immunological Synapses and Kinapses in Lymph Nodes

10 Oct 2016

publication

In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

22 Jun 2016

project

Think tank: Cancer

12 Jan 2016

publication

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

21 Dec 2015

publication

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

01 Oct 2015

publication

Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection

08 Sep 2015

software

Dynamic In Situ Cytometry

07 Sep 2015

project

ERC-2010-StG LymphocyteContacts

15 Jun 2015

project

Lymphocyte activation in lymphoid organs

15 Jun 2015

project

Immune responses during infections

15 Jun 2015

project

Immune responses following transplantation

15 Jun 2015

project

Immune responses against tumors

11 May 2015

team

Dynamics of Immune Responses

15 Sep 2014

department

Immunology

28 Jul 2014

publication

Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors

10 Mar 2014

publication

Collective nitric oxide production provides tissue-wide immunity during Leishmania infection

24 Nov 2013

publication

Visualizing how T cells collect activation signals in vivo

01 Nov 2013

publication

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

16 Oct 2013

publication

Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism

08 Jul 2013

publication

Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division

15 Mar 2013

publication

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

15 Feb 2013

publication

Shigella impairs T lymphocyte dynamics in vivo

01 Jan 2013

publication

Dynamics of NK cell interactions in vivo

01 Dec 2012

publication

Functional immunoimaging: the revolution continues

26 Nov 2012

publication

Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions

15 Nov 2012

publication

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

26 Oct 2012

publication

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory

12 Oct 2012

publication

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

20 Sep 2012

publication

How many dendritic cells are required to initiate a T-cell response?

01 Jul 2012

publication

DISC: a guide to in vivo cytometry

21 Jun 2012

publication

CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation

07 Jun 2012

publication

Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo

01 Jun 2012

publication

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer

01 Jan 2012

publication

Mathematical model of tumor immunotherapy for bladder carcinoma identifies the limitations of the innate immune response

08 Dec 2011

publication

Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery

01 Aug 2011

publication

Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation

27 May 2011

publication

Chronic infections capture little attention of the masses

15 May 2011

publication

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy

28 Apr 2011

publication

A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation

22 Dec 2010

publication

Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells

19 Oct 2010

publication

Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues

14 Oct 2010

publication

Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression

24 Sep 2010

publication

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

01 Apr 2010

publication

Signal 0 for guided priming of CTLs: NKT cells do it too

04 Feb 2010

publication

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

10 Aug 2009

publication

Dynamic behavior of NK cells during activation in lymph nodes

23 Jul 2009

publication

A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection

01 Sep 2008

publication

T-cell activation by dendritic cells in the lymph node: lessons from the movies

01 Sep 2008

publication

Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming

01 Apr 2008

publication

Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice

01 Feb 2008

publication

Decoding the dynamics of T cell-dendritic cell interactions in vivo

01 Jan 2008

publication

Intravital two-photon imaging of natural killer cells and dendritic cells in lymph nodes

18 Oct 2007

publication

Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation

02 Mar 2007

publication

Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion

01 Feb 2007

publication

Imaging the immunological synapse

01 Jan 2007

publication

Intravital two-photon imaging of T-cell priming and tolerance in the lymph node

01 Aug 2006

publication

Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells

12 Jun 2006

publication

Cellular orchestration of T cell priming in lymph nodes

01 Jan 2006

publication

Lymph node choreography: Treg cells join the dance

07 Nov 2005

publication

CD4 T cells integrate signals delivered during successive DC encounters in vivo

01 Sep 2004

publication

Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy

01 Aug 2004

publication

Real-time imaging of T-cell development

01 Oct 2003

publication

Visualizing thymocyte motility using 2-photon microscopy

05 May 2003

publication

Dynamics of CD8+ T cell priming by dendritic cells in intact lymph nodes

15 Sep 2002

publication

TNF-mediated toxicity after massive induction of specific CD8+ T cells following immunization of mice with a tumor-specific peptide

01 Jun 2002

publication

A little guide for advanced search:

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

Pasteur International Cancer Conference 2023

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.

Inflammation triggers ILC3 patrolling of the intestinal barrier.

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

New publication – High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing, Nature Communications, June 3, 2022

High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing.

Quorum sensing governs collective dendritic cell activation in vivo.

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

Cancer: CAR T cell function scrutinized to improve immunotherapy

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

Save the date: 20–22 October 2021 Meeting of Institut Pasteur and CIML

Improving immunotherapies for blood cancers: real-time exploration in the tumor

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

Department of Immunology seminar: Andrew Oberst, Too important to die: New antiviral roles for “cell death” pathways in the brain

U1223 – Pathophysiology of the immune system

The immune system profoundly restricts intratumor genetic heterogeneity

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

A human immune system mouse model with robust lymph node development.

Development and function of dendritic cell subsets

ERC 2017-Advanced Grant ENLIGTHEN

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

Microchannels for the Study of T Cell Immunological Synapses and Kinapses

In Vivo Imaging of T Cell Immunological Synapses and Kinapses in Lymph Nodes

In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.

Think tank: Cancer

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection

Dynamic In Situ Cytometry

ERC-2010-StG LymphocyteContacts

Lymphocyte activation in lymphoid organs

Immune responses during infections

Immune responses following transplantation

Immune responses against tumors

Dynamics of Immune Responses

Immunology

Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors

Collective nitric oxide production provides tissue-wide immunity during Leishmania infection

Visualizing how T cells collect activation signals in vivo

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism

Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

Shigella impairs T lymphocyte dynamics in vivo

Dynamics of NK cell interactions in vivo

Functional immunoimaging: the revolution continues

Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

How many dendritic cells are required to initiate a T-cell response?

DISC: a guide to in vivo cytometry

CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation

Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer

Mathematical model of tumor immunotherapy for bladder carcinoma identifies the limitations of the innate immune response

Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery

Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation

Chronic infections capture little attention of the masses

Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy

A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation

Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells

Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues

Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

Signal 0 for guided priming of CTLs: NKT cells do it too

Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes

Dynamic behavior of NK cells during activation in lymph nodes

A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection

T-cell activation by dendritic cells in the lymph node: lessons from the movies