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© Research
Publication : Nature reviews. Immunology

T-cell activation by dendritic cells in the lymph node: lessons from the movies

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Immunology - 01 Sep 2008

Bousso P

Link to Pubmed [PMID] – 19172690

Nat. Rev. Immunol. 2008 Sep;8(9):675-84

Interactions between T cells and dendritic cells (DCs) in the lymph nodes are crucial for initiating cell-mediated adaptive immune responses. With the help of two-photon imaging, the complexity of these cellular contacts in vivo has recently been captured in time-lapse movies in several immunological contexts. Well beyond the satisfaction of seeing a T-cell response as it happens, these experiments provide fundamental insights into the regulation and the biological meaning of T-cell-DC contact dynamics. This Review focuses on how this emerging field is changing our perception of T-cell activation by DCs.

http://www.ncbi.nlm.nih.gov/pubmed/19172690