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© Research
Publication : The Journal of experimental medicine

CD4 T cells integrate signals delivered during successive DC encounters in vivo

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of experimental medicine - 07 Nov 2005

Celli S, Garcia Z, Bousso P

Link to Pubmed [PMID] – 16275764

J. Exp. Med. 2005 Nov;202(9):1271-8

The cellular mode of T cell priming in vivo remains to be characterized fully. We investigated the fate of T cell-dendritic cell (DC) interactions in the late phase of T cell activation in the lymph node. In general, CD4 T cells detach from DCs before undergoing cell division. Using a new approach to track the history of antigen (Ag)-recognition events, we demonstrated that activated/divided T cells reengage different DCs in an Ag-specific manner. Two-photon imaging of intact lymph nodes suggested that T cells could establish prolonged interactions with DCs at multiple stages during the activation process. Importantly, signals that are delivered during subsequent DC contacts are integrated by the T cell and promote sustained IL-2Ralpha expression and IFN-gamma production. Thus, repeated encounters with Ag-bearing DCs can occur in vivo and modulate CD4 T cell differentiation programs.

https://www.ncbi.nlm.nih.gov/pubmed/16275764