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  • whocc
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  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
15
Jun 2015
Status
Ongoing
Members
3
Structures
1
Publications
6

About

Intracellular pathogens have developed strategies to survive in infected cells and reduce their recognition by the innate and adaptive immune systems. Our lab wishes to define the mechanisms influencing the recognition of infected cells by effector lymphocytes in vivo. In addition, we aim to better understand the set of interactions that effector CD4 and CD8 T cells need to establish to resolve infection in peripheral tissue.

infections movie 1

CD4 T cells patrolling the dermis at the site of Leishmania major infections. Intravital imaging was performed in the ear skin of mice infected with L. major parasites (red). Macrophages and neutrophils are green, parasite-specific T cells are brown and indicated by a circle.
Click here to see the movie

infections movies 2Hotspot of antigen recognition at the site of Leishmania major infection. Parasite specific T cells (green) stably interact with a limited number of L. major (red) infected cells. The area of contact is shown in white.
Click here to see the movie

 

Fundings

References