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© Research
Publication : Current opinion in immunology

Visualizing how T cells collect activation signals in vivo

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 24 Nov 2013

Moreau HD, Bousso P

Link to Pubmed [PMID] – 24556401

Curr. Opin. Immunol. 2014 Feb;26:56-62

A decade ago the first movies depicting T cell behavior in vivo with the help of two-photon microscopy were generated. These initial experiments revealed that T cells migrate rapidly and randomly in secondary lymphoid organs at steady state and profoundly alter their behavior during antigen recognition, establishing both transient and stable contacts with antigen-presenting cells (APCs). Since then, in vivo imaging has continuously improved our understanding of T cell activation. In particular, recent studies uncovered how T cells may be guided in their search for the best APCs. Additionally, the development of more sophisticated fluorescent tools has permitted not only to visualize T cell-APC contacts but also to probe their functional impact on T cell activation. These recent progresses are providing new insights into how T cells sense antigen, collect activation signals during distinct types of interaction and integrate information over successive encounters.

http://www.ncbi.nlm.nih.gov/pubmed/24556401