Inserm Unit 1223 (Pathophysiology of the Immune System) comprises four laboratories within the Immunology Department of the Institut Pasteur: Innate Immunity Unit (James Di Santo), Lymphocytes and Immunity Unit (Ana Cumano), Dynamics of Immune Response Unit (Philippe Bousso) and Genome Integrity Immunity and Cancer Unit (Ludovic Deriano). Together, we pursue collaborative projects aiming to better understand lymphocyte development, differentiation and functional dynamics under normal steady-state conditions and during inflammation or infection in mouse and man.
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About
Members
Groups
Laboratory
Dynamics of Immune Responses
Philippe Bousso
Laboratory
Lymphocytes and Immunity
Ana Cumano
Laboratory
Innate Immunity
James Di Santo
Fundings
Publications
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2022Epitope convergence of broadly HIV-1 neutralizing IgA and IgG antibody lineages in a viremic controller., J Exp Med 2022 Mar; 219(3): .
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2022Trained ILC3 responses promote intestinal defense., Science 2022 Feb; 375(6583): 859-863.
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2022Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency., Blood 2022 02; (): .
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2022CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages., J Exp Med 2022 Feb; 219(2):e20210987.
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2022The (Lack of) DNA Double-Strand Break Repair Pathway Choice During V(D)J Recombination, Frontiers in Genetics.
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2022Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein., J Biol Chem 2022 01; 298(1): 101290.
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2021Our latest edition of Flow Cytometry Guidelines for basic and clinical immunologists!, Eur J Immunol 2021 12; 51(12): 2703.
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2021Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)., Eur J Immunol 2021 12; 51(12): 2708-3145.
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2021Fam72a enforces error-prone DNA repair during antibody diversification, Nature . 2021 Dec;600(7888):329-333. .
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2021Release of infectious virus and cytokines in nasopharyngeal swabs from individuals infected with non-alpha or alpha SARS-CoV-2 variants: an observational retrospective study., EBioMedicine 2021 Nov; 73(): 103637.
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