Inserm Unit 1223 (Pathophysiology of the Immune System) comprises four laboratories within the Immunology Department of the Institut Pasteur: Innate Immunity Unit (James Di Santo), Lymphocytes and Immunity Unit (Ana Cumano), Dynamics of Immune Response Unit (Philippe Bousso) and Genome Integrity Immunity and Cancer Unit (Ludovic Deriano). Together, we pursue collaborative projects aiming to better understand lymphocyte development, differentiation and functional dynamics under normal steady-state conditions and during inflammation or infection in mouse and man.
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About
Groups
Laboratory
Dynamics of Immune Responses
Philippe Bousso
Laboratory
Innate Immunity
James Di Santo
Laboratory
Genome integrity, Immunity and Cancer
Ludovic Deriano
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Fundings
Publications
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2025Spatiotemporal dynamics of fetal liver hematopoietic niches., J Exp Med 2025 Feb; 222(2): .
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2024IL-7-dependent and -independent lineages of IL-7R-dependent human T cells., J Clin Invest 2024 Oct; 134(19): .
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2024Group 3 innate lymphoid cells: A trained Gutkeeper., Immunol Rev 2024 May; 323(1): 126-137.
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2024A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: candidate selection in a preclinical murine model., J Virol 2024 Apr; (): e0169323.
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2024Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes., J Exp Med 2024 Apr; 221(4): .
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2024Bone marrow monocytes sustain NK cell-poiesis during non-alcoholic steatohepatitis, Cell Reports, 2024, 43 (1), pp.113676. ⟨10.1016/j.celrep.2024.113676⟩.
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2023Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation., Proc Natl Acad Sci U S A 2023 Oct; 120(40): e2306761120.
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2023A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy, Cell Reports Medicine, 2023, 4 (9), pp.101161. ⟨10.1016/j.xcrm.2023.101161⟩.
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2023A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses., Eur J Immunol 2023 Aug; (): e2350454.
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2023Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity., Nat Cancer 2023 Jul; 4(7): 968-983.
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