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  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
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  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
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  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
15
Jun 2015
Status
Ongoing
Members
3
Structures
1
Publications
1

About

Transplant rejection involves a coordinated attack of donor cells by the innate and the adaptive immune system of the host. To gain insight into this dynamic process, we have developed an ear skin graft model suitable for intravital imaging. We are defining the critical steps regulating chronic and acute rejection with the aim of identifying new strategies to reduce the occurrence of graft rejection.

transplantation movie 1Intravital imaging of a skin graft. Recipient infiltrating cells are shown in yellow, donor Langerhans cells in red, collagen fibers in the dermis in green.
Click here to see the movie

 

transplantation movie 2CD8+ T cells accumulate in the recipient tissue around the graft. The donor/recipient edges were imaged by two-photon microscopy. Blood vessels are shown in red, collagen fibers in green, CD8+ T cells in yellow.
Click here to see the movie

 

Fundings