Ligne de temps
Philippe Bousso
Responsable de Structure
01 avr. 2024
publication
Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.
Lire plus25 mars 2024
news
New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes
Lire plus15 août 2023
publication
A major role for CD4+ T cells in driving cytokine release syndrome during CAR T cell therapy.
Lire plus05 juin 2023
news
New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity
Lire plus29 mai 2023
publication
Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.
Lire plus17 mai 2023
17 févr. 2023
publication
Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.
Lire plus29 août 2022
23 août 2022
publication
SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse.
Lire plus23 août 2022
19 juil. 2022
publication
Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.
Lire plus03 juin 2022
news
New publication – High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing, Nature Communications, June 3, 2022
Lire plus03 juin 2022
publication
High resolution microfluidic assay and probabilistic modeling reveal cooperation between T cells in tumor killing.
Lire plus14 juin 2021
15 avr. 2021
publication
Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.
Lire plus02 avr. 2021
26 mars 2021
publication
A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.
Lire plus15 mars 2021
19 févr. 2021
01 févr. 2021
publication
Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.
Lire plus09 mars 2020
publication
Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment
Lire plus01 mars 2020
publication
Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.
Lire plus04 avr. 2019
event
Department of Immunology seminar: Andrew Oberst, Too important to die: New antiviral roles for “cell death” pathways in the brain
Lire plus14 févr. 2019
23 nov. 2018
19 sept. 2018
publication
A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses
Lire plus01 août 2018
04 juin 2018
07 mai 2018
27 mars 2018
publication
Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division
Lire plus01 janv. 2017
01 janv. 2017
10 oct. 2016
publication
In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models.
Lire plus22 juin 2016
12 janv. 2016
publication
The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation
Lire plus21 déc. 2015
publication
In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity
Lire plus01 oct. 2015
publication
Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection
Lire plus08 sept. 2015
07 sept. 2015
15 juin 2015
15 juin 2015
15 juin 2015
15 juin 2015
11 mai 2015
15 sept. 2014
28 juil. 2014
publication
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors
Lire plus10 mars 2014
publication
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection
Lire plus24 nov. 2013
01 nov. 2013
publication
The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging
Lire plus16 oct. 2013
publication
Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism
Lire plus08 juil. 2013
publication
Phenotypic CD8+ T cell diversification occurs before, during, and after the first T cell division
Lire plus15 mars 2013
publication
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
Lire plus15 févr. 2013
01 janv. 2013
01 déc. 2012
26 nov. 2012
publication
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions
Lire plus15 nov. 2012
publication
Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis
Lire plus26 oct. 2012
publication
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory
Lire plus12 oct. 2012
publication
Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
Lire plus20 sept. 2012
01 juil. 2012
21 juin 2012
publication
CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation
Lire plus07 juin 2012
publication
Dynamic in situ cytometry uncovers T cell receptor signaling during immunological synapses and kinapses in vivo
Lire plus01 juin 2012
publication
Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer
Lire plus01 janv. 2012
publication
Mathematical model of tumor immunotherapy for bladder carcinoma identifies the limitations of the innate immune response
Lire plus08 déc. 2011
publication
Immunization route dictates cross-priming efficiency and impacts the optimal timing of adjuvant delivery
Lire plus01 août 2011
publication
Cutting Edge: A dual role for type I IFNs during polyinosinic-polycytidylic acid-induced NK cell activation
Lire plus27 mai 2011
15 mai 2011
publication
Visualizing the innate and adaptive immune responses underlying allograft rejection by two-photon microscopy
Lire plus28 avr. 2011
publication
A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation
Lire plus22 déc. 2010
publication
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells
Lire plus19 oct. 2010
publication
Quantifying subcellular distribution of fluorescent fusion proteins in cells migrating within tissues
Lire plus14 oct. 2010
publication
Intravital imaging reveals distinct dynamics for natural killer and CD8(+) T cells during tumor regression
Lire plus24 sept. 2010
publication
Visualizing the functional diversification of CD8+ T cell responses in lymph nodes
Lire plus01 avr. 2010
04 févr. 2010
publication
Subcellular dynamics of T cell immunological synapses and kinapses in lymph nodes
Lire plus10 août 2009
23 juil. 2009
publication
A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection
Lire plus01 sept. 2008
publication
T-cell activation by dendritic cells in the lymph node: lessons from the movies
Lire plus01 sept. 2008
publication
Antigen persistence is required for dendritic cell licensing and CD8+ T cell cross-priming
Lire plus01 avr. 2008
publication
Two-photon imaging of intratumoral CD8+ T cell cytotoxic activity during adoptive T cell therapy in mice
Lire plus01 févr. 2008
01 janv. 2008
publication
Intravital two-photon imaging of natural killer cells and dendritic cells in lymph nodes
Lire plus18 oct. 2007
publication
Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation
Lire plus02 mars 2007
publication
Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion
Lire plus01 févr. 2007
01 janv. 2007
publication
Intravital two-photon imaging of T-cell priming and tolerance in the lymph node
Lire plus01 août 2006
publication
Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells
Lire plus12 juin 2006
01 janv. 2006
07 nov. 2005
publication
CD4 T cells integrate signals delivered during successive DC encounters in vivo
Lire plus01 sept. 2004
publication
Dynamic behavior of T cells and thymocytes in lymphoid organs as revealed by two-photon microscopy
Lire plus01 août 2004
01 oct. 2003
05 mai 2003
15 sept. 2002
publication
TNF-mediated toxicity after massive induction of specific CD8+ T cells following immunization of mice with a tumor-specific peptide
Lire plus01 juin 2002
publication