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© Research
Publication : Science (New York, N.Y.)

Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy

Team: Dynamics of Immune Responses
Member: Philippe Bousso
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 01 Jun 2002

Bousso P, Bhakta NR, Lewis RS, Robey E

Link to Pubmed [PMID] – 12052962

Science 2002 Jun;296(5574):1876-80

Thymocytes are selected to mature according to their ability to interact with self major histocompatibility complex (MHC)-peptide complexes displayed on the thymic stroma. Using two-photon microscopy, we performed real-time analysis of the cellular contacts made by developing thymocytes undergoing positive selection in a three-dimensional thymic organ culture. A large fraction of thymocytes within these cultures were highly motile. MHC recognition was found to increase the duration of thymocyte-stromal cell interactions and occurred as both long-lived cellular associations displaying stable cell-cell contacts and as shorter, highly dynamic contacts. Our results identify the diversity and dynamics of thymocyte interactions during positive selection.