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  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2018
Ending Date
31
Dec 2022
Status
Ongoing
Members
1
Structures
2

About

To fight cancer or infections, a variety of immune cells are engaged in a tremendously complex, yet highly coordinated sequence of cellular processes. This coordination is enforced by distinct mechanisms of cellular communication allowing immune cells i) to sense information from their environment and from other cells and ii) to respond to this information by altering their behavior, gaining functional properties or propagating new information in the tissue. Immune cells exchange information with each other and with their environment through two major modes: i) the formation of cell-cell interactions and ii) the production of diffusible mediators such as cytokines and chemokines. Cell-cell interactions certainly contribute to ensure that the information is passed specifically to an individual cell at a given time and in a given location. In addition, immune cells communicate at greater distances through the activity of cytokines and chemokines. These mediators may be present in large territories of the microenvironment, potentially acting on many cells simultaneously. The last decades have witnessed immunologists elucidate an impressive number of mechanisms involved in the initiation and resolution of immune responses. However, the integration of all these mechanisms into the in vivo context remains extraordinarily challenging. Two outstanding scientific questions will constitute the basis for the present reserach program.

How do immune cells integrate and respond to cellular contacts in lymphoid organs and in tumors? 

How does the immunological information propagate in tissues through the activity of cytokines and chemokines?