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  • program_project
  • nrc
  • whocc
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  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
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  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
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  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
15
Jun 2015
Status
Ongoing
Members
4
Structures
1
Publications
6

About

Cytotoxic T cells and NK cells (CTLs) are key players of anti-tumor immune responses. Despite our fundamental knowledge on the interplay between the immune system and tumor microenvironments, we have a poor understanding on the efficiency with which intratumoral immune effectors find, interact and kill their targets. Intratumoral imaging provide the opportunity to better understand how these events occur and change during the course of tumor development and why immune responses often fail to eradicate tumors.

tumors movie 1Infitration of cytotoxic T cells in solid tumors. Tumor-specific CTLs (orange) migrating and interacting in a subcutaneous solid tumor. Tumor cells expressed a membrane YFP molecule.
Click here to see the movie

tumors movie 2Killing of tumor cells by CTLs visualized using a FRET based probe for apoptosis. The movie shows three examples of tumor cells undergoing apoptosis upon interaction with CTLs (red). Tumor cells expressed a FRET-based probe for caspase 3 activation. Live tumor cells appears in yellow and apoptotic tumor cells in green.
Click here to see the movie

tumors movie 3NK cells establish dynamic interactions with tumor cells. NK cells (yellow) infiltrating a solid tumor establish primarily short-lived interactions with Rae1-β expressing tumor cells (red).
Click here to see the movie

Fundings

References