Biology of Infection

2 Members

ERC-CoG INVADIS

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]

Completed

2 Members

ERC-StG MICROTRANS

Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]

6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]

3 Members

Microbial translocation across the intestinal epithelium (ANR, Organolist)

Olivier Disson (PI)

We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.

5 Members

Host responses to microbial intestinal invasion, impact on microbial dissemination

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]

Listeria monocytogenes invasion of the placenta

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]

3 Members

Listeria monocytogenes invasion of the central nervous system

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]

Subversive pro- and anti-inflammation trade-offs promote infection by Listeria monocytogenes (Infect-ERA, PROANTILIS)

Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]

15 Members

Genomic taxonomy of bacterial strains: universal nomenclatures for epidemiology and population biology

Sylvain Brisse (PI)

High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]

15 Members

When Gut Bacteria Changes Brain Functions

Pierre-Marie Lledo (PI)

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]

8 Members

Human and ruminant neurolisteriosis: a comparative study (Swiss National Science Foundation, Sinergia)

Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]

Caroline Charlier-Woerther (PI)

LISTERIAGEN (ANR)

The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.

Caroline Charlier-Woerther (PI)

5 Members

MONALISA: A Multicentric Observational National Analysis on Listeriosis and Listeria (PHRC)

MONALISA is a prospective national study on invasive listeriosis. It aims to identify risk and prognostic factors for invasive listeriosis and to dissect the clinical and biological features of each form of infection (septicemia, central nervous […]

Chikungunya virus pathogenesis

Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection

5 Members

Enterovirus EV71 pathogenesis