Systemic infections result from the invasion of hosts by microbial pathogens. A critical pathogenic determinant of microbes is their capacity to translocate from the external environment into the host across mucosal barriers, disseminate systemically and reach protected tissues such as the central nervous system and the fetus. Our research is focused on understanding the molecular mechanisms underlying the ability of microbes to target specifically host cells, cross mucosal, blood-brain and placental barriers, disseminate systemically and within tissues.
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Members
Former Members
2000
2000
Name
Position
2008
2009
Solène Grayo
PhD Student
2009
2009
Florent Laferrière
Undergraduate Student
2008
2010
Georgios Nikitas
PhD Student
2008
2011
Nicolas Gangneux
Technician
2009
2011
Chantal Deschamps
Post-doc
2012
2012
Delphine Judith
PhD Student
2010
2014
Yu-Huan Tsai
Post-doc
2011
2014
Cindy Fèvre
Post-doc
2008
2014
Corinne Baran
Administrative Staff
2014
2014
Nathalie Barilone
Technician
2014
2014
Yende Grell
Undergraduate Student
2008
2015
Viviane Chenal-Francisque
Research Engineer
2005
2015
Martine Belin
Administrative Staff
2015
2015
Sophia Robertson-Lavalle
Undergraduate Student
2013
2015
Magatte Fall
Clinical Research Assistant
2015
2015
Anne Paria
Undergraduate Student
2011
2016
Camille Bleriot
Post-doc
2013
2016
Stefano Berre
Post-doc
2015
2016
Melissa Hanson
Post-doc
2012
2016
Grégoire Gessain
PhD Student
2014
2017
Alessia Galgano
Post-doc
2015
2017
Aurélie Du Thanh
Post-doc
2015
2017
Marie Ramirez
Technician
2014
2018
Charlotte Gaultier
PhD Student
2016
2018
Marie-Claire Rozier
Administrative Staff
2018
2018
Nathalie Bousquet
Administrative Staff
2014
2019
Christiane Bouchier
Permanent Researcher
2014
2019
Marc Eloit
Head of Structure
2014
2019
Philippe Pérot
Research Engineer
2018
2019
Lei Huang
PhD Student
2015
2019
Mylène Maury
Research Engineer
2010
2021
Laetitia Travier
Research Engineer
2020
2021
Sophie Nusser
Undergraduate Student
2021
2022
Afonso de Sousa Viera
Undergraduate Student
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Projects
Transversal Project
Fundings
Partners
Featured publications
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2022Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence., Nature volume 603, pages 900–906 (2022).
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2022Neonatal Listeriosis Presentation and Outcome: A Prospective Study of 189 Cases., Clin Infect Dis 2022 01; 74(1): 8-16.
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2021Emergence and global spread of Listeria monocytogenes main clinical clonal complex., Sci Adv 2021 Dec; 7(49): eabj9805.
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2021Listeria monocytogenes faecal carriage is common and depends on the gut microbiota., Nat Commun 2021 11; 12(1): 6826.
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2021Neonatal susceptibility to meningitis results from the immaturity of epithelial barriers and gut microbiota., Cell Rep 2021 06; 35(13): 109319.
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2021COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters., Sci Transl Med 2021 06; 13(596): .
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2021Live Imaging Reveals Listeria Hijacking of E-Cadherin Recycling as It Crosses the Intestinal Barrier., Curr Biol 2021 03; 31(5): 1037-1047.e4.
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2021Innate immune responses to Listeria in vivo., Curr Opin Microbiol 2021 02; 59(): 95-101.
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2020Maternal-neonatal listeriosis., Virulence 2020 12; 11(1): 391-397.
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2020Listeria valentina sp. nov., isolated from a water trough and the faeces of healthy sheep., Int J Syst Evol Microbiol 2020 Nov; 70(11): 5868-5879.
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2020Listeria monocytogenes, a model in infection biology., Cell Microbiol 2020 04; 22(4): e13186.
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2020Outbreak of Listeriosis in South Africa Associated with Processed Meat., N Engl J Med 2020 02; 382(7): 632-643.
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2019A Listeria monocytogenes Bacteriocin Can Target the Commensal Prevotella copri and Modulate Intestinal Infection., Cell Host Microbe 2019 11; 26(5): 691-701.e5.
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2019FHL1 is a major host factor for chikungunya virus infection., Nature 2019 10; 574(7777): 259-263.
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2019IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise., Science 2019 07; 365(6449): 176-180.
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2019Hypervirulent Listeria monocytogenes clones’ adaption to mammalian gut accounts for their association with dairy products., Nat Commun 2019 06; 10(1): 2488.
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2018Peyer’s patch myeloid cells infection by Listeria signals through gp38+ stromal cells and locks intestinal villus invasion., J Exp Med 2018 11; 215(11): 2936-2954.
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2018Epistatic control of intrinsic resistance by virulence genes in Listeria., PLoS Genet 2018 09; 14(9): e1007525.
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2018Lessons learnt from the emergence of Zika virus., Nat Microbiol 2018 09; 3(9): 966-968.
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2018Stress-induced unfolded protein response contributes to Zika virus-associated microcephaly., Nat Neurosci 2018 01; 21(1): 63-71.
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2017Arboviruses and pregnancy: maternal, fetal, and neonatal effects., Lancet Child Adolesc Health 2017 Oct; 1(2): 134-146.
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2017Real-Time Whole-Genome Sequencing for Surveillance of Listeria monocytogenes, France, Emerging Infect. Dis. 2017 09;23(9):1462-1470.
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2017Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study., Lancet Infect Dis 2017 05; 17(5): 510-519.
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2016Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes., Nat Microbiol 2016 Oct; 2(): 16185.
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2016A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs., Nat Commun 2016 05; 7(): 11320.
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2016Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity., Nat Genet 2016 Mar; 48(3): 308-313.
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2016Chikungunya virus-associated encephalitis: A cohort study on La Réunion Island, 2005-2009., Neurology 2016 Jan; 86(1): 94-102.
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2015Chikungunya virus and the global spread of a mosquito-borne disease, N. Engl. J. Med. 2015 Mar;372(13):1231-9.
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2015PI3-kinase activation is critical for host barrier permissiveness to Listeria monocytogenes., J Exp Med 2015 Feb; 212(2): 165-83.
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2015Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection., Immunity 2015 Jan; 42(1): 145-58.
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2014Global burden of listeriosis: the tip of the iceberg., Lancet Infect Dis 2014 Nov; 14(11): 1027-1028.
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2013Species-specific impact of the autophagy machinery on Chikungunya virus infection., EMBO Rep 2013 Jun; 14(6): 534-44.
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2013ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage., PLoS Pathog 2013 Jan; 9(1): e1003131.
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2013Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses., PLoS Pathog 2013 ; 9(5): e1003381.
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2012Impact of lactobacilli on orally acquired listeriosis., Proc Natl Acad Sci U S A 2012 Oct; 109(41): 16684-9.
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2011Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin., J Exp Med 2011 Oct; 208(11): 2263-77.
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2010Entrapment of intracytosolic bacteria by septin cage-like structures., Cell Host Microbe 2010 Nov; 8(5): 433-44.
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2010The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates, J. Exp. Med. 2010 Oct;207(11):2313-22.
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2010Type I IFN controls chikungunya virus via its action on nonhematopoietic cells., J Exp Med 2010 Feb; 207(2): 429-42.
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2009The Listeria transcriptional landscape from saprophytism to virulence., Nature 2009 Jun; 459(7249): 950-6.
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2008Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis., Nature 2008 Oct; 455(7216): 1114-8.
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2008Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion, PLoS Med. 2008 Mar;5(3):e60.
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2008A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease., PLoS Pathog 2008 Feb; 4(2): e29.
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2007A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system., Proc Natl Acad Sci U S A 2007 Jan; 104(3): 997-1002.
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2005ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion., Nat Cell Biol 2005 Oct; 7(10): 954-60.
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2004Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin., Proc Natl Acad Sci U S A 2004 Apr; 101(16): 6152-7.
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2004Immunoproliferative small intestinal disease associated with Campylobacter jejuni, N. Engl. J. Med. 2004 Jan;350(3):239-48.
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2001A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier., Science 2001 Jun; 292(5522): 1722-5.
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2000A role for alpha-and beta-catenins in bacterial uptake., Proc Natl Acad Sci U S A 2000 Aug; 97(18): 10008-13.
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1999A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes., EMBO J 1999 Jul; 18(14): 3956-63.
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Phone: +33 (0)1 40 61 37 87 Email: marc.lecuit@pasteur.fr Address: Institut Pasteur Biology of Infection Unit, Inserm U1117 28, Rue du Docteur Roux 75015, Paris France