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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique

About

Systemic infections result from the invasion of hosts by microbial pathogens. A critical pathogenic determinant of microbes is their capacity to translocate from the external environment into the host across mucosal barriers, disseminate systemically and reach protected tissues such as the central nervous system and the fetus. Our research is focused on understanding the molecular mechanisms underlying the ability of microbes to target specifically host cells, cross mucosal, blood-brain and placental barriers, disseminate systemically and within tissues.

Members

Marc Lecuit
Head of Structure
Head
Thérèse Couderc
Permanent Researcher
Olivier Disson
Permanent Researcher
Alexandra Moura
Research Associate
Claire Maudet-Crépin
Post-doc
Minhee Kim
Post-doc
Hana Kammoun
Post-doc
Marouane Kheloufi
Post-doc
Lukas Hafner
PhD Student
Sylvain Levallois
PhD Student
Julien Gaillard
PhD Student
Thibaud Goupil
PhD Student
Melody Dazas
Technician
Alexandre Leclercq
Deputy Director of National Reference Center
Caroline Charlier-Woerther
Physician
Hélène Bracq-Dieye
Technician
Pierre Thouvenot
Technician
Guillaume Vales
Technician
Nathalie Tessaud Rita
Technician
Sofieya Vijayaratnam
Clinical Research Assistant
Andrée Diakité
Administrative Staff
Afonso de Sousa Vieira
Research Engineer
Lydie Couturier
Research Engineer

Former Members

2000
2000
Name
Position
2008
2009
Solène Grayo
PhD Student
2009
2009
Florent Laferrière
Undergraduate Student
2008
2010
Georgios Nikitas
PhD Student
2008
2011
Nicolas Gangneux
Technician
2009
2011
Chantal Deschamps
Post-doc
2012
2012
Delphine Judith
PhD Student
2010
2014
Yu-Huan Tsai
Post-doc
2011
2014
Cindy Fèvre
Post-doc
2008
2014
Corinne Baran
Administrative Staff
2014
2014
Nathalie Barilone
Technician
2014
2014
Yende Grell
Undergraduate Student
2008
2015
Viviane Chenal-Francisque
Research Engineer
2005
2015
Martine Belin
Administrative Staff
2015
2015
Sophia Robertson-Lavalle
Undergraduate Student
2013
2015
Magatte Fall
Clinical Research Assistant
2015
2015
Anne Paria
Undergraduate Student
2011
2016
Camille Bleriot
Post-doc
2013
2016
Stefano Berre
Post-doc
2015
2016
Melissa Hanson
Post-doc
2012
2016
Grégoire Gessain
PhD Student
2014
2017
Alessia Galgano
Post-doc
2015
2017
Aurélie Du Thanh
Post-doc
2015
2017
Marie Ramirez
Technician
2014
2018
Charlotte Gaultier
PhD Student
2016
2018
Marie-Claire Rozier
Administrative Staff
2018
2018
Nathalie Bousquet
Administrative Staff
2014
2019
Christiane Bouchier
Permanent Researcher
2014
2019
Marc Eloit
Head of Structure
2014
2019
Philippe Pérot
Research Engineer
2018
2019
Lei Huang
PhD Student
2015
2019
Mylène Maury
Research Engineer
2010
2021
Laetitia Travier
Research Engineer
2020
2021
Sophie Nusser
Undergraduate Student
Show all

Projects

Project
Ongoing
2 Members

ERC-CoG INVADIS

Marc Lecuit (PI)

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]
Project
Completed
2 Members

ERC-StG MICROTRANS

Marc Lecuit (PI)

Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]
Project
Not started
6 Members

(SOCSET) Studying Olfactory and Cognitive Symptoms Evolution in long-COVID Patients

Erwan Poivet (PI)

Sudden loss of smell is a common symptom associated with COVID-19 and SARS-CoV-2 infection of neurons in the olfactory system has been reported in both hamsters and humans. The vast majority of patients with […]
Project
Ongoing
6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Project
Ongoing
3 Members

Microbial translocation across the intestinal epithelium (ANR, Organolist)

Olivier Disson (PI)

We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.
Project
Ongoing
5 Members

Host responses to microbial intestinal invasion, impact on microbial dissemination

Marc Lecuit (PI)

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Project
Ongoing
4 Members

Listeria monocytogenes invasion of the placenta

Marc Lecuit (PI)

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]
Project
Ongoing
3 Members

Listeria monocytogenes invasion of the central nervous system

Marc Lecuit (PI)

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]
Project
Ongoing
4 Members

Subversive pro- and anti-inflammation trade-offs promote infection by Listeria monocytogenes (Infect-ERA, PROANTILIS)

Marc Lecuit (PI)

Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]
Project
Ongoing
15 Members

Genomic taxonomy of bacterial strains: universal nomenclatures for epidemiology and population biology

Sylvain Brisse (PI)

High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]
Project
Ongoing
15 Members

When Gut Bacteria Changes Brain Functions

Pierre-Marie Lledo (PI)

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Project
Ongoing
8 Members

Human and ruminant neurolisteriosis: a comparative study (Swiss National Science Foundation, Sinergia)

Marc Lecuit (PI)

Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]
Project
Ongoing
4 Members

LISTERIAGEN (ANR)

Caroline Charlier-Woerther (PI)

The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.
Project
Ongoing
5 Members

MONALISA: A Multicentric Observational National Analysis on Listeriosis and Listeria (PHRC)

Caroline Charlier-Woerther (PI)

MONALISA is a prospective national study on invasive listeriosis. It aims to identify risk and prognostic factors for invasive listeriosis and to dissect the clinical and biological features of each form of infection (septicemia, central nervous […]
Project
Ongoing
4 Members

Chikungunya virus pathogenesis

Marc Lecuit (PI)

Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection  
Project
Ongoing
5 Members

Enterovirus EV71 pathogenesis

Marc Lecuit (PI)

This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.

Transversal Project

Brain connectivity and neurodegenerative diseases

The brain is a complex organ, and its well-being depends on the harmonic interactions with the rest of our body. Nearly all brain disorders manifest themselves in the dysfunction of communication between brain cells […]

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

Antimicrobial resistance

Antimicrobial resistance is dramatically increasing worldwide and is becoming one of the most urgent public health threats. There is an urgent need for actions to reverse the curve of antimicrobial resistance dissemination and to […]

Ageing & Longevity

According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception’s goal is to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in a range of health issues (Official website here : https://www.inception-program.fr/en). Inception program […]

Major Federating Program Microbes & Brain

Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]

The Southeast Asia encephalitis project

  An integrative approach to understand and fight infectious encephalitis in children An encephalitis is an acute inflammation of the central nervous system associated with neurologic dysfunction. The most common etiologies are infections by […]

The institut Carnot Pasteur MS

Carnot, label of excellence Founded in 2006, the Carnot Label, granted by the French government, was designed to develop partnership-based research, meaning research conducted by public laboratories in partnership with socio-economic players, primarily industry […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]

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Munchen 200515b

Contact

Phone: +33 (0)1 40 61 37 87 Email: marc.lecuit@pasteur.fr Address: Institut Pasteur Biology of Infection Unit, Inserm U1117 28, Rue du Docteur Roux 75015, Paris France