Biology of Infection

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]

Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]

We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]

Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]

High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]

Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]

The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.

MONALISA is a prospective national study on invasive listeriosis. It aims to identify risk and prognostic factors for invasive listeriosis and to dissect the clinical and biological features of each form of infection (septicemia, central nervous […]

Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection  

This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.