It is now clear that immune cells, classically known for their role in fighting infection, play key roles in brain development, homeostasis, and disease. Our lab is interested in better understanding the interactions between immune cells and the brain, and the role of these communication circuits in shaping brain function in physiology, aging and disease. Our approach encompasses scRNA-seq and other technologies of genomics, classical tools of immunology, neuroscience, and everything else that could help us identify the mechanisms of brain-immune communication.
Immune activity at the brain borders
Immune cells modulate CNS activities in physiology, but peripheral immune cells are rarely found in direct contact with the neural tissue. Instead, the immune cells are thought to affect the brain remotely and indirectly, […]
Microglia are extremely specialized immune cells, which reside in the CNS and play key roles in its development, homeostasis and disease. Such specialization is imposed by the peculiar environment the microglia have to live […]
2021XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis., Nat Med 2021 May; (): .
2020Advancing brain barriers RNA sequencing: guidelines from experimental design to publication., Fluids Barriers CNS 2020 Aug; 17(1): 51.
2018The Fountain of Youth: It’s All in Our Veins., Neuron 2018 10; 100(1): 9-11.
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