It is now clear that immune cells, classically known for their role in fighting infection, play key roles in brain development, homeostasis, and disease. Our lab is interested in better understanding the interactions between immune cells and the brain, and the role of these communication circuits in shaping brain function in physiology, aging and disease. Our approach encompasses scRNA-seq and other technologies of genomics, classical tools of immunology, neuroscience, and everything else that could help us identify the mechanisms of brain-immune communication.
Research Engineer Position in Bioinformatics at Institut Pasteur Paris
Position: The Bioinformatics and Biostatistics Hub at Institut Pasteur is hiring a research engineer in bioinformatics, for an ERC-funded 4.5-year-long “CDI projet” contract with the potential to evolve into a full CDI after this […]
Immune activity at the brain borders
Immune cells modulate CNS activities in physiology, but peripheral immune cells are rarely found in direct contact with the neural tissue. Instead, the immune cells are thought to affect the brain remotely and indirectly, […]
Microglia are extremely specialized immune cells, which reside in the CNS and play key roles in its development, homeostasis and disease. Such specialization is imposed by the peculiar environment the microglia have to live […]
Drug Discovery & Screening at Institut Pasteur
The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]
2023Chelator PBT2 Forms a Ternary Cu2+ Complex with β-Amyloid That Has High Stability but Low Specificity., Int J Mol Sci 2023 May; 24(11): .
2023Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties., Nat Commun 2023 May; 14(1): 2553.
2022Microbial and immune factors regulate brain maintenance and aging., Curr Opin Neurobiol 2022 Jul; 76(): 102607.
2022The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response., Nat Cancer 2022 03; 3(3): 303-317.
2022Isolation and Characterization of the Immune Cells from Micro-dissected Mouse Choroid Plexuses, JoVE J. 2022 ().
2021XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis., Nat Med 2021 May; (): .
2021NASH limits anti-tumour surveillance in immunotherapy-treated HCC., Nature 2021 Apr; 592(7854): 450-456.
2021Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies., Life Sci Alliance 2021 Jan; 4(1): .
2020Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients., Cell 2020 Jun; 181(7): 1475-1488.e12.
2019Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner., Cell 2019 Jul; 178(3): 686-698.e14.
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