About

The Virology Department is constituted by 21 principal investigators with their research units, covering most aspects of contemporary virology with a special emphasis on human pathogenic viruses.

The department houses different National Reference Centres and WHO Collaborating Centres for viruses. Our primary mission is to remain at the cutting edge of fundamental research and, at the same time, close to applications in global public health issues.

Most of the members of the Department are involved in teaching in the two post-graduate virology courses of Institut Pasteur.

The research teams have many collaborations within and between departments on campus, and at the national and international level, including the Institut Pasteur international network and with numerous hospitals.

Scientific background and interests

The viruses that the Virology Department study are diverse, including oncogenic viruses, that cause cancer (hepatitis viruses, papillomavirus, herpesvirus and HTLV), retroviruses (HIV, HTLV and foamy viruses – as well as their simian counterparts), respiratory viruses (influenza virus, respiratory syncytial virus), arboviruses (flaviviruses, alphaviruses, bunyaviruses).

Other viruses studied include picornaviruses, rhabdoviruses and paramyxoviruses such as measles and parainfluenza viruses. Highly pathogenic agents such as Lassa and Nipah viruses are studied in the context of the biosafety level 4 facilities in Lyon.

The Department’s research aims at understanding the molecular mechanisms at play during the different steps of the viral cycle. A large effort is currently being made to decipher virus/host interactions, and physio-pathological events associated with virus infection. The Department’s research includes:

  • The molecular and cellular mechanisms of the viral cycle – cell entry and uncoating, genome replication, particle assembly, egress.
  • The pathogenesis of viruses causing different diseases (cancer; immunodeficiency; neurological, respiratory, enteric and hepatic diseases).
  • The dissemination of the virus within the organism (crossing of anatomical barriers), between hosts and in the environment – transmission, zoonoses, animal reservoirs and vectors, entomology.
  • The innate and acquired immunity to virus infection, both at the cellular and host level, the activity of host restriction factors, and the countermeasures of virus evasion.
  • The molecular modelling of viral replication, virus structure, enzymology.
  • The population genetics and dynamics of virus and host –  molecular and clinical epidemiology and phylogeny, virus and host genomics and transcriptomics, determinants of virus and host susceptibility or resistance, adaptation and evolution.
  • The development of innovative antiviral approaches (antiviral compounds, vaccines, gene therapy).
  • The use of cutting-edge technology for virus discovery and to improve diagnostics.

 

News

Events

SEMINAR OF THE VIROLOGY DEPARTMENT

Building: LWoff – Room: salle retrovirus (salle 014) – Address: 25 - 28 Rue du Docteur Roux, Paris, France
2017-01-18 12:00:00 2017-01-18 13:00:00 Europe/Paris SEMINAR OF THE VIROLOGY DEPARTMENT Rodney COLINA  Director del Laboratorio de Virología Molecular  Universidad de la República – Salto (Uruguay) Environmental surveillance as a tool to map circulation frequency and genetic diversity of gastroenteric viruses in a particular region   […] 25 - 28 Rue du Docteur Roux, Paris, France

GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”

Building: Lwoff – Room: Room 14 , ground floor – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2017-04-18 16:00:00 2017-04-18 18:00:00 Europe/Paris GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission” Speakers : Romulus BREBAN, Jade GHOSN ,   Nathalie DEJUCQ —————- Romulus BREBAN Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris Meta-analysis of the residual risk of sexual HIV transmission from efficiently treated persons     […] Institut Pasteur, Rue du Docteur Roux, Paris, France

Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”

Building: Lwoff – Room: 14 RdC – Address: 28 Rue du Dr Roux, 75015 Paris, France
2017-11-21 16:00:00 2017-11-21 18:00:00 Europe/Paris Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies” Organizer:  Lisa CHAKRABARTI, for the GRS organization committee Unité de Pathogénie Virale, Institut Pasteur, Paris   Speakers :  Frédéric TANGY Unité de Génomique Virale et Vaccination, Institut Pasteur, Paris Protective efficacy of live measles-HIV vaccine […] 28 Rue du Dr Roux, 75015 Paris, France

Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”

Building: Lwoff – Room: 14 RdC – Address: 28 Rue du Dr Roux, Paris, France
2018-02-16 16:00:00 2018-02-16 18:00:00 Europe/Paris Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV” Organizer : Asier SAEZ-CIRION, for the GRS organization committee Unité HIV, Inflammation, et Persistance, Institut Pasteur, Paris   Speakers :  Mireille LAFORGE UFR Biomédicale, Université Paris Descartes Impact de la morphogenèse mitochondriale sur le métabolisme […] 28 Rue du Dr Roux, Paris, France

GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”

Address: 25 Rue du Dr Roux, 75015 Paris, France
2018-03-13 16:00:00 2018-03-13 18:00:00 Europe/Paris GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection” Organizer :  Jade GHOSN UF de Thérapeutique en Immuno-Infectiologie, Hôtel Dieu, Paris Speakers : Dominique COSTAGLIOLA INSERM, Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris Restauration immunitaire chez les PVVIH initiant […] 25 Rue du Dr Roux, 75015 Paris, France

“Functional CURE under some ENIGMATIC mechanisms: Choke-and-Mute, rather than Shoot-and-Kill ?” by Jacques Leibowitch – VIROLOGY DEPARTMENT SEMINAR

Building: Centre François Jacob – Room: Auditorium Centre François Jacob – Address: 28 Rue du Docteur Roux, Paris, France
2018-05-17 11:00:00 2018-05-17 12:00:00 Europe/Paris “Functional CURE under some ENIGMATIC mechanisms: Choke-and-Mute, rather than Shoot-and-Kill ?” by Jacques Leibowitch – VIROLOGY DEPARTMENT SEMINAR VIROLOGY DEPARTMENT SEMINAR Jacques LEIBOWITCH  Anti HIV Maintenance Therapy Intermittent, in Close Cycles, Anti Retrovirals Retain Efficacy ICCARRE and its 3 days, 2 days, 1 day a week cycles, open the chapter of Long Lasting Post […] 28 Rue du Docteur Roux, Paris, France

Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies”

Building: Lwoff – Room: 14 RdC – Address: 28 Rue du Dr Roux, 75015 Paris, France
2018-06-12 16:00:00 2018-06-12 18:00:00 Europe/Paris Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies” Organizers :  Hugo MOUQUET and Lisa CHAKRABARTI Pasteur Institute, Paris Speakers : Guillemette MASSE-RANSON Innate Immunity Unit, Pasteur Institute, Paris Combining immunotherapies in HIV-infected Human Immune System (HIS) mice Yu Chun LONE Lwoff Institute, Paris South University and INSERM UMR1197, […] 28 Rue du Dr Roux, 75015 Paris, France

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