A 2 year Research Engineer position is open to study novel immune modulating therapies to Hepatitis B virus (HBV) infections, using humanized mouse models, at the Institut Pasteur Paris in the Department of Immunology.
Current treatment strategies for HBV are life-long and rarely curative. Although HBV infects hepatocytes, its evasion and modulation of the immune response is key to the physiopathology observed.
The goal is to analyze the immune response to HBV during and after treatment with a novel combination using an immune modulating therapy and antiviral developed by an industrial partner, using an immune competent humanized mouse model. The anti-HBV immune responses and virological parameters will be monitored, to determine the efficacy of the compounds and whether robust immune responses may be restored, leading to functional cure.
The project is funded through a collaboration with an industrial partner. The Institut Pasteur in Paris is recognized worldwide as a leader in the field of infectious disease research and is ranked as a top-level institution for publication impact in microbiology and infectious diseases. Research is organized in 130 research units in 11 thematic departments, covering a wide-range of subjects including microbiology and infectious diseases, immunology, neuroscience, developmental biology, genetics and cancer. The candidate will join the Group Humanized mice for infectious disease modeling, in the Innate Immunity Unit within the Immunology Department.
Candidates should have a PhD with strong background in Immunology and/or Virology, technical expertise with murine models, FACS, molecular biology and cell culture. Applicants should be highly motivated, well organized, proficient in English, and able to work independently as well as collaboratively.
Applicants should send their CV, a letter of motivation including a summary of previous research experience, and contact information for two references to Helene Strick-Marchand (firstname.lastname@example.org).