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  • Physician
  • Post-doc
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  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
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About

Caroline Demangel trained in the National Institute of Agronomy Paris-Grignon (AgroParisTech). After a PhD in Biotechnology in the Bertin company (Plaisir, France), she opted for a career in academic research. She did a post-doc in the Centenary Institute (Sydney, Australia), designing and testing anti-tuberculous vaccines that target dendritic cells in Warwick Britton’s Lab. Back in Paris in 2002, she joined the team of Stewart Cole at the Institut Pasteur to develop novel approaches to mycobacterial disease diagnosis and treatment, with a particular focus on Leprosy and Buruli ulcer disease. Since 2011, she’s been directing the “Immunobiology and Infection” Unit in the Immunology Department of the Pasteur Institute. Her team studies the mechanisms by which pathogenic mycobacteria establish chronic infections in humans, in particular the bacterial virulence factors interfering with host immunity. The aim of these studies is to find innovative approaches to better treat mycobacterial infections, and identify novel natural compounds with immunomodulatory potential.

Projects

Project
Ongoing
5 Members

Therapeutic potential of mycolactone surrogates

Caroline Demangel (PI)

Inflammation adversely affects the health of millions of people worldwide and there is an unmet medical need for better anti-inflammatory drugs. Our group evaluates the therapeutic interest of mycolactone, a polyketide-derived macrolide produced by […]
Project
Ongoing
5 Members

Mycolactone of M. ulcerans and immunodulation

Caroline Demangel (PI)

Mycolactone is a diffusible macrolide produced by Mycobacterium ulcerans, the causative agent of a chronic skin disease called Buruli ulcer. Defective cellular immune responses, at the local and systemic levels, are hallmarks of Buruli […]
Project
Ongoing
2 Members

Biomarkers of Buruli ulcer disease

Caroline Demangel (PI)

Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Project
Ongoing
3 Members

Mycobacterial phenolic glycolipids and innate host defenses

Caroline Demangel (PI)

Across different species of mycobacteria, phenolic glycolipids (PGL) share a common lipid core and phenol ring that are embedded in the cell envelope, and differ in the saccharidic portion that is exposed on the […]
Project
Ongoing
4 Members

Mycolactone of M. ulcerans and the actin cytoskeleton

Caroline Demangel (PI)

A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]

Publications

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