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© Institut Pasteur/Antoinette Ryter
Coupe de Mycobacterium bovis ou bacille de Calmette et Guérin (BCG). Souche atténuée de bacille vivant, à l'origine du vaccin antituberculeux délivré par voie intradermique ou scarifications (Grossissement X 70000). Image colorisée.

About

Caroline Demangel studied life sciences at the National Institute of Agronomy Paris-Grignon (AgroParisTech), where she completed her PhD in cell biotechnology. She worked as a postdoctoral fellow on antibody engineering at Institut Pasteur, where she was offered a staff scientist position. Then, she joined the mycobacteria research group led by Warwick Britton at the Centenary Institute in Sydney, Australia to design and test innovative Tuberculous subunit vaccines targeting dendritic cells. She returned to Institut Pasteur after four years to develop novel approaches to the diagnosis and prevention of neglected mycobacterial diseases, particularly Buruli ulcer and Leprosy, as an scientist in  Stewart Cole’s lab then as an independent group leader. Since 2011, she’s been directing a research unit in the Immunology Department, where she currently serves as deputy director. Her group investigates the microbe-immune system dialogue to identify novel bioactive molecules and therapeutic strategies to manipulate immunity.

Transversal Projects

Emerging Infectious Diseases

Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]

LabEx Milieu Intérieur

The Milieu Intérieur project provides insight into the core of human diversity by dissecting the interplay between genetics and environment and their impact on the immune system. https://www.youtube.com/watch?v=IXlKElDJMc8 The Milieu Intérieur Project While the […]

Projects

Project
Completed
5 Members

Host fatty acids and immunity to Mycobacterium tuberculosis

Caroline Demangel (PI)

While the special relationship between Mycobacterium tuberculosis (Mtb) and host lipids has long been known, it remains a challenging enigma. It was clearly established that Mtb requires host fatty acids (FAs) and cholesterol to […]
Project
Ongoing
13 Members

Deciphering the causes of Hidradenitis Suppurativa

Caroline Demangel (PI)

Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Project
Ongoing
8 Members

Therapeutic potential of mycolactone and synthetic surrogates

Caroline Demangel (PI)

Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Project
Ongoing
5 Members

Immunity against Mycobacterium ulcerans : the subversive role of mycolactone

Caroline Demangel (PI)

Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]
Project
Ongoing
5 Members

Biomarkers of Buruli ulcer disease

Caroline Demangel (PI)

Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Project
Completed
3 Members

Mycobacterial phenolic glycolipids and innate host defenses

Caroline Demangel (PI)

Across different species of mycobacteria, phenolic glycolipids (PGL) share a common lipid core and phenol ring that are embedded in the cell envelope, and differ in the saccharidic portion that is exposed on the […]
Project
Completed
4 Members

Mycolactone of Mycobacterium ulcerans and the actin cytoskeleton

Caroline Demangel (PI)

A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]

Publications

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