Caroline Demangel trained in the National Institute of Agronomy Paris-Grignon (AgroParisTech). After a PhD in Biotechnology in the Bertin company (Plaisir, France), she opted for a career in academic research. She did a post-doc in the Centenary Institute (Sydney, Australia), designing and testing anti-tuberculous vaccines that target dendritic cells in Warwick Britton’s Lab. Back in Paris in 2002, she joined the team of Stewart Cole at the Institut Pasteur to develop novel approaches to mycobacterial disease diagnosis and treatment, with a particular focus on Leprosy and Buruli ulcer disease. Since 2011, she’s been directing the “Immunobiology and Infection” Unit in the Immunology Department of the Pasteur Institute. Her team studies the mechanisms by which pathogenic mycobacteria establish chronic infections in humans, in particular the bacterial virulence factors interfering with host immunity. The aim of these studies is to find innovative approaches to better treat mycobacterial infections, and identify novel natural compounds with immunomodulatory potential.
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Publications
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2018Parallel derivation of isogenic human primed and naive induced pluripotent stem cells, Nat Commun 2018 Jan;9(1):360.
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2018Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages, Front Immunol 2018;9:2.
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2017Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges, Proc. Natl. Acad. Sci. U.S.A. 2018 Jan;115(3):E488-E497.
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2017Mycolactone displays anti-inflammatory effects on the nervous system, PLoS Negl Trop Dis 2017 Nov;11(11):e0006058.
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2017Modular total syntheses of mycolactone A/B and its [(2)H]-isotopologue, Org. Biomol. Chem. 2017 Sep;15(36):7518-7522.
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2017Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export, Proc. Natl. Acad. Sci. U.S.A. 2017 Jul;114(29):E5910-E5919.
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2017Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells, EMBO J. 2017 Jun;36(12):1653-1668.
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2017Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids, Biochimie 2017 Mar;.
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2016Mycolactone subverts immunity by selectively blocking the Sec61 translocon, J. Exp. Med. 2016 Dec;213(13):2885-2896.
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2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses, Cell Rep 2016 09;16(10):2777-2791.
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