Caroline Demangel studied life sciences at the National Institute of Agronomy Paris-Grignon (AgroParisTech), where she completed her PhD in cell biotechnology. She worked as a postdoctoral fellow on antibody engineering at Institut Pasteur, where she was offered a staff scientist position. Then, she joined the mycobacteria research group led by Warwick Britton at the Centenary Institute in Sydney, Australia to design and test innovative Tuberculous subunit vaccines targeting dendritic cells. She returned to Institut Pasteur after four years to develop novel approaches to the diagnosis and prevention of neglected mycobacterial diseases, particularly Buruli ulcer and Leprosy, as an scientist in Stewart Cole’s lab then as an independent group leader. Since 2011, she’s been directing a research unit in the Immunology Department, where she currently serves as deputy director. Her group investigates the microbe-immune system dialogue to identify novel bioactive molecules and therapeutic strategies to manipulate immunity.
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2023Host-pathogen interactions from a metabolic perspective: methods of investigation., Microbes Infect 2023 Nov; (): 105267.
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2023From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone., Toxins (Basel) 2023 May; 15(6): .
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2023Nutrient-dependent regulation of β-cell proinsulin content., J Biol Chem 2023 May; (): 104836.
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2023Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity., Immunol Rev 2023 Mar; (): .
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2023Click-chemistry-based protocol to quantitatively assess fatty acid uptake by Mycobacterium tuberculosis in axenic culture and inside mouse macrophages., STAR Protoc 2023 Jan; 4(1): 102062.
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2023Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma., Front Oncol 2023 ; 13(): 1110916.
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2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
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2022Mycolactone Purification from M. ulcerans Cultures and HPLC-Based Approaches for Mycolactone Quantification in Biological Samples., Methods Mol Biol 2022 ; 2387(): 117-130.
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2022Biochemical and Biological Assays of Mycolactone-Mediated Inhibition of Sec61., Methods Mol Biol 2022 ; 2387(): 163-181.
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2021De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis., Elife 2021 Dec; 10(): .
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