Caroline Demangel studied life sciences at the National Institute of Agronomy Paris-Grignon (AgroParisTech), where she completed her PhD in cell biotechnology. She worked as a postdoctoral fellow on antibody engineering at Institut Pasteur, where she was offered a staff scientist position. Then, she joined the mycobacteria research group led by Warwick Britton at the Centenary Institute in Sydney, Australia to design and test innovative Tuberculous subunit vaccines targeting dendritic cells. She returned to Institut Pasteur after four years to develop novel approaches to the diagnosis and prevention of neglected mycobacterial diseases, particularly Buruli ulcer and Leprosy, as an scientist in Stewart Cole’s lab then as an independent group leader. Since 2011, she’s been directing a research unit in the Immunology Department, where she currently serves as deputy director. Her group investigates the microbe-immune system dialogue to identify novel bioactive molecules and therapeutic strategies to manipulate immunity.
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2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 Jan; (): e14740.
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2021De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis., Elife 2021 Dec; 10(): .
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2021Insights into the ancestry evolution of the Mycobacterium tuberculosis complex from analysis of Mycobacterium riyadhense., NAR Genom Bioinform 2021 Sep; 3(3): lqab070.
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2021Immunity against Mycobacterium ulcerans: The subversive role of mycolactone., Immunol Rev 2021 Feb; (): .
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2021Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis., Immunol Rev 2021 Feb; (): .
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2021Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities., Front Immunol 2021 ; 12(): 747387.
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2021Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone., Front Pharmacol 2021 ; 12(): 733496.
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2020Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
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2020Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system., PLoS Negl Trop Dis 2020 Dec; 14(12): e0008878.
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2020Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 10; 370(6515): .
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