Caroline Demangel, born in 1966, studied biology at the National Institute of Agronomy Paris-Grignon (AgroParisTech) and earned her PhD in Biotechnology in 1992. She worked as a postdoctoral fellow on antibody engineering at Institut Pasteur, where she was offered an Assistant Member position in 1996. In 1998, she moved to the Centenary Institute in Sydney to design and test Tuberculous subunit vaccines targeting dendritic cells. She returned to Institut Pasteur in 2002 as an Assistant Professor with the goal of developing novel approaches to diagnosis and prevention of neglected mycobacterial diseases, particularly Buruli ulcer and Leprosy. She was promoted to Associate Professor in 2008. Since 2011, she’s been directing the “Immunobiology and Infection” Unit in the Immunology Department. Her current work is focused on the strategies evolved by mycobacterial pathogens to suppress immunity, in particular those targeting host immune cell metabolism.
Host fatty acids and immunity to Mycobacterium tuberculosis
While the special relationship between Mycobacterium tuberculosis (Mtb) and host lipids has long been known, it remains a challenging enigma. It was clearly established that Mtb requires host fatty acids (FAs) and cholesterol to […]
Deciphering the causes of Hidradenitis Suppurativa
Hidradenitis Suppurativa (HS), also known as Verneuil’s disease and acne inversa, is an incurable skin disease manifesting as recurrent, invalidating abscesses. In addition to causing intense pain, HS is commonly associated with disability, depression […]
Therapeutic potential of mycolactone and synthetic surrogates
Whether released by bacteria infecting the skin or injected via the subcutaneous route, mycolactone was found to diffuse into the leukocytes of peripheral blood and lymphoid organs. With this distribution profile, the unique effects […]
Immunity against Mycobacterium ulcerans : the subversive role of mycolactone
Mycobacterium ulcerans causes Buruli ulcer, a neglected tropical skin disease manifesting as chronic wounds that can leave victims with major, life-long deformity and disability. Differently from other mycobacteria, including the related M. tuberculosis and […]
Biomarkers of Buruli ulcer disease
Buruli ulcer is the third most common mycobacterial disease after Tuberculosis and Leprosy. It is a chronic, necrotizing disease of the skin and soft tissues that is reported in over thirty tropical and subtropical […]
Mycobacterial phenolic glycolipids and innate host defenses
Across different species of mycobacteria, phenolic glycolipids (PGL) share a common lipid core and phenol ring that are embedded in the cell envelope, and differ in the saccharidic portion that is exposed on the […]
Mycolactone of Mycobacterium ulcerans and the actin cytoskeleton
A distinctive feature of the human pathogen Mycobacterium ulcerans is the production of mycolactone. This original polyketide-derived macrolide is essential for bacterial virulence and sufficient to induce ulcerative lesions in the skin that are […]
2021Immunity against Mycobacterium ulcerans: The subversive role of mycolactone., Immunol Rev 2021 Feb; (): .
2021Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis., Immunol Rev 2021 Feb; (): .
2020Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
2020Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system., PLoS Negl Trop Dis 2020 Dec; 14(12): e0008878.
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 10; 11(1): 5239.
2020Mycolactone induces cell death by SETD1B-dependent degradation of glutathione., 2020 Oct; 14(10): e0008709.
2020Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
2020Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 10; 370(6515): .
2019CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy, Front Immunol 2019;10:2913.
2019Recombinant Antibodies against Mycolactone, Toxins (Basel) 2019 Jun;11(6).
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