Chromatin modifications, at the level of histones, are fundamental regulators of gene expression in eukaryotes as they control the access of the transcriptional machinery to the targeted promoter regions. Recent studies have found that chromatin modifications induced by bacterial pathogens interfere with the host transcriptional program. However, the mechanisms at play are poorly characterized and the role of these modifications for the host or for the bacterium remain unknown. Research in our team is centered on this new facet of host-pathogen interactions using 2 bacterial models, Listeria monocytogenes and Streptococcus pneumoniae, a pathogen and a natural colonizer respectively. The main goal of our research is to characterize the role of chromatin modifications induced upon bacteria-host interactions and their long term consequences. Our work is at the interface between microbiology, chromatin biology/epigenetics and innate immunity. This multidisciplinary approach will allow the discovery of strategies used by bacteria to reprogram host transcription either during colonization or acute infection, and also provide new insight into fundamental cellular processes such as tolerance to prolonged stimulation and epigenetic memory. In addition, understanding bacteria-induced epigenomic regulation of immune responses could transform our view of immunological memory in vertebrates thereby leading to the development of new antimicrobial agents.
Therapeutic tools based on nucleic acids
An important research axis of the laboratory is to modify nucleic acids with chemical groups in order to improve their therapeutic usefulness. Particularly, modified aptamers (i.e. oligonucleotides capable of binding to targets with high […]
Emerging Infectious Diseases
Ever since its very early days, the Institut Pasteur has been committed to tackling emerging infections, and its work has left an extraordinary legacy. Many emerging infectious diseases are zoonoses, in which an animal […]
Fighting Antibiotic Resistance
Antibiotics are highly efficient drugs to kill pathogenic bacteria with low side effects. For more than 70 years, the massive use of these miracle drugs has saved millions of human and animal lives. Unfortunately […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
2020The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae., Nat Microbiol 2020 Dec; (): .
2020Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses by, Toxins (Basel) 2020 May;12(5).
2020Targeting host epigenetic machinery: The Listeria paradigm, Cell. Microbiol. 2020 Apr;22(4):e13169.
2020Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase, Cell Rep 2020 Mar;30(12):4016-4026.e4.
2020Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins, Sci Rep 2020 Feb;10(1):2034.
2020Revealing eukaryotic histone-modifying mechanisms through bacterial infection, Semin Immunopathol 2020 Feb;.
2019H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation, Cell Rep 2019 Dec;29(12):3933-3945.e3.
2019Customizing Host Chromatin: a Bacterial Tale, Microbiol Spectr 2019 03;7(2).
2018Rapid Remodeling of the Host Epithelial Cell Proteome by the Listeriolysin O (LLO) Pore-forming Toxin, Mol. Cell Proteomics 2018 08;17(8):1627-1636.
2018Infection Reveals a Modification of SIRT2 Critical for Chromatin Association., Cell Rep 2018 04; 23(4): 1124-1137.
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