Chromatin modifications, at the level of histones, are fundamental regulators of gene expression in eukaryotes as they control the access of the transcriptional machinery to the targeted promoter regions. Recent studies have found that chromatin modifications induced by bacterial pathogens interfere with the host transcriptional program. However, the mechanisms at play are poorly characterized and the role of these modifications for the host or for the bacterium remain unknown. Research in our team is centered on this new facet of host-pathogen interactions using 2 bacterial models, Listeria monocytogenes and Streptococcus pneumoniae, a pathogen and a natural colonizer respectively. The main goal of our research is to characterize the role of chromatin modifications induced upon bacteria-host interactions and their long term consequences. Our work is at the interface between microbiology, chromatin biology/epigenetics and innate immunity. This multidisciplinary approach will allow the discovery of strategies used by bacteria to reprogram host transcription either during colonization or acute infection, and also provide new insight into fundamental cellular processes such as tolerance to prolonged stimulation and epigenetic memory. In addition, understanding bacteria-induced epigenomic regulation of immune responses could transform our view of immunological memory in vertebrates thereby leading to the development of new antimicrobial agents.
Click to view graph
Connections
Members
Former Members
2000
2000
Name
Position
(FR) 2016
(FR) 2016
(FR) Paul Primard
(FR) Medecine Student
(FR) 2017
(FR) 2018
(FR) Kayley Pate
(FR) Master Student
(FR) 2015
(FR) 2018
(FR) Jorge Pereira
(FR) PhD Student
(FR) 2018
(FR) 2019
(FR) Emma Patey
(FR) Master student
(FR) 2016
(FR) 2019
(FR) Orhan Rasid
(FR) Post-doc
(FR) 2016
(FR) 2020
(FR) Wenyang Dong
(FR) PhD Student
(FR) 2019
(FR) 2021
(FR) Matthew Eldridge
(FR) Post-doc
Calls
Projects
Transversal Project
Fundings
Publications
Download-
2021Histone H3 deacetylation promotes host cell viability for efficient infection by Listeria monocytogenes., PLoS Pathog 2021 Dec; 17(12): e1010173.
-
2021Mitochondrial respiration restricts Listeria monocytogenes infection by slowing down host cell receptor recycling., Cell Rep 2021 Nov; 37(6): 109989.
-
2021The histone demethylase KDM6B fine-tunes the host response to Streptococcus pneumoniae., Nat Microbiol 2021 02; 6(2): 257-269.
-
2020Pathogenic Biohacking: Induction, Modulation and Subversion of Host Transcriptional Responses by, Toxins (Basel) 2020 May;12(5).
-
2020Targeting host epigenetic machinery: The Listeria paradigm, Cell. Microbiol. 2020 Apr;22(4):e13169.
-
2020Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase, Cell Rep 2020 Mar;30(12):4016-4026.e4.
-
2020Active nuclear import of the deacetylase Sirtuin-2 is controlled by its C-terminus and importins, Sci Rep 2020 Feb;10(1):2034.
-
2020Revealing eukaryotic histone-modifying mechanisms through bacterial infection, Semin Immunopathol 2020 Feb;.
-
2019H3K4me1 Supports Memory-like NK Cells Induced by Systemic Inflammation, Cell Rep 2019 Dec;29(12):3933-3945.e3.
-
2019Customizing Host Chromatin: a Bacterial Tale, Microbiol Spectr 2019 03;7(2).
-
+View full list of publications