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© Lucie Peduto, Institut Pasteur
Stroma du ganglion lymphatique
Publication : Current opinion in immunology

Mesenchymal perivascular cells in immunity and disease

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 05 May 2020

Benabid A, Peduto L

Link to Pubmed [PMID] – 32387900

Curr. Opin. Immunol. 2020 May;64:50-55

The mesenchymal microenvironment is increasingly recognized as a major player in immunity. Here we focus on mesenchymal cells located within or in proximity to the blood vessels wall, which include pericytes, adventitial fibroblasts and mesenchymal stromal cells. We discuss recent evidence that these cells play a role in tissue homeostasis, immunity and inflammatory pathologies by multiple mechanisms, including vascular modulation, leucocyte migration, activation or survival in the perivascular space and differentiation into specialized ‘effector’ mesenchymal cells essential for tissue repair and immunity, such as myofibroblasts and lymphoid stromal cells. When dysregulated, these responses contribute to inflammatory and fibrotic diseases.

https://www.ncbi.nlm.nih.gov/pubmed/32387900