Timeline

François Schweisguth
Head of Structure
12 Feb 2019
team

Genetic, molecular and cellular bases of development

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01 Feb 2019
publication

Mechanisms of Notch signaling: a simple logic deployed in time and space

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23 Nov 2018
event

DSCB and C3BI Departments Seminar by Professor Stein Aerts, Department of Human Genetics, Laboratory of Computational Biology, KU Leuven

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19 Nov 2018
publication

Spen limits intestinal stem cell self-renewal

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23 Oct 2018
event

Developmental and Stem Cell Biology Department seminar by Doctor Abderrahman Khila, Developmental Genomics and Evolution team, Institut de Génomique Fonctionnelle de Lyon

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23 May 2018
event

BDCS Department seminar by Professor Norbert Perrimon, Harvard Medical School, Boston, USA

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17 Nov 2017
publication

Spatial regulation of contractility by Neuralized and Bearded during furrow invagination in Drosophila

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03 Nov 2017
publication

Regulation of cortical stability by RhoGEF3 in mitotic sensory organ precursor cells in Drosophila

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21 Sep 2017
publication

Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?

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20 Jul 2017
publication

Intra-lineage Fate Decisions Involve Activation of Notch Receptors Basal to the Midbody in Drosophila Sensory Organ Precursor Cells

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10 Apr 2017
publication

Neuralized regulates Crumbs endocytosis and epithelium morphogenesis via specific Stardust isoforms

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06 Apr 2017
publication

Self-organized Notch dynamics generate stereotyped sensory organ patterns in Drosophila

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31 Mar 2017
event

SEMINAR ” Stem cells, diet, and physiology” by Professor Daniela Drummond-Barbosa

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15 Feb 2017
event

SEMINAR “Design principles of cell-cell signaling processes” by David Sprinzak

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23 Jan 2017
publication

Response to “Does pupal communication influence Wolbachia-mediated cytoplasmic incompatibility?”

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09 Jan 2017
event

SEMINAR “The varied roles of Notch in building the body plan”

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12 Apr 2016
publication

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling

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21 Sep 2015
publication

A Wolbachia-Sensitive Communication between Male and Female Pupae Controls Gamete Compatibility in Drosophila

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10 Jul 2015
program_project

LabEx Revive – Regenerative biology & medicine

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07 Jun 2015
project

Epithelial morphogenesis

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11 May 2015
team

Drosophila Developmental Genetics

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07 May 2015
project

Cell polarity and asymmetric cell division

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30 Apr 2015
project

Cell biology of Notch

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07 Apr 2015
project

Stem cells and tissue homeostasis

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02 Apr 2015
publication

Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells

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01 Mar 2015
project

Bristle patterning: positional information and self-organization

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28 Feb 2015
project

Sex, Gamete Compatibility, Pheromones and Endosymbiots

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29 Jan 2015
project

Regulatory genomics – Imogene

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23 Jan 2015
publication

Asymmetric cell division in the Drosophila bristle lineage: from the polarization of sensory organ precursor cells to Notch-mediated binary fate decision

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03 Nov 2014
publication

A fluorescent tagging approach in Drosophila reveals late endosomal trafficking of Notch and Sanpodo

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15 Sep 2014
department

Developmental and Stem Cell Biology

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05 Jun 2014
publication

Insensible is a novel nuclear inhibitor of Notch activity in Drosophila

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25 Mar 2014
publication

Imogene: identification of motifs and cis-regulatory modules underlying gene co-regulation

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01 Jan 2014
publication

Antibody uptake assay and in vivo imaging to study intracellular trafficking of Notch and Delta in Drosophila

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12 Aug 2013
publication

Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells

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10 May 2013
publication

Inhibition of Notch recycling by Numb: relevance and mechanism(s)

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21 Mar 2013
publication

Numb localizes at endosomes and controls the endosomal sorting of notch after asymmetric division in Drosophila

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22 Oct 2012
publication

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

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08 Oct 2012
publication

Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling

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15 Apr 2012
publication

Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila

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22 Jan 2012
publication

Endocytosis by Numb breaks Notch symmetry at cytokinesis

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28 Oct 2011
publication

Glycosphingolipids in signaling and development: from liposomes to model organisms

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28 Sep 2011
publication

Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine

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11 Jan 2011
publication

Mechanism and significance of cis-inhibition in Notch signalling

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29 Jul 2010
publication

Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny

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21 Apr 2010
publication

Neuralized promotes basal to apical transcytosis of delta in epithelial cells

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01 Mar 2010
publication

Transcriptional control of stem cell maintenance in the Drosophila intestine

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22 Feb 2010
publication

Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster

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25 Aug 2009
publication

Notch signalling: receptor cis-inhibition to achieve directionality

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15 Jun 2009
publication

Genome engineering-based analysis of Bearded family genes reveals both functional redundancy and a nonessential function in lateral inhibition in Drosophila

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01 Mar 2009
publication

When you are Dishevelled, fat is good and acid is bad!

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13 Feb 2009
publication

Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division

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27 Aug 2008
publication

Overexpression of partner of numb induces asymmetric distribution of the PI4P 5-Kinase Skittles in mitotic sensory organ precursor cells in Drosophila

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01 Jan 2008
publication

Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy?

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04 Jan 2007
publication

aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb

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15 Dec 2006
publication

Transcription of bxd noncoding RNAs promoted by trithorax represses Ubx in cis by transcriptional interference

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01 Feb 2006
publication

Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila

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01 Dec 2005
publication

The Notch ‘gospel’

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01 Nov 2005
publication

Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division

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24 May 2005
publication

Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and Sanpodo in Drosophila sensory-organ precursor cells

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20 May 2005
publication

Temporal regulation of planar cell polarity: insights from the Drosophila eye

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01 Apr 2005
publication

The roles of receptor and ligand endocytosis in regulating Notch signaling

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15 Mar 2005
publication

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila

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04 Aug 2004
publication

Evolution of the larval peripheral nervous system in Drosophila species has involved a change in sensory cell lineage

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01 Jun 2004
publication

Formation and remodeling of epithelial polarity

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01 May 2004
publication

Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila

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01 Apr 2004
publication

[Genetic basis of planar polarity]

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01 Feb 2004
publication

Asymmetric localization and function of cell-fate determinants: a fly’s view

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01 Feb 2004
publication

Regulation of notch signaling activity

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01 Jan 2004
publication

The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila

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01 Aug 2003
publication

Cell polarity: the ups and downs of the Par6/aPKC complex

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01 Jul 2003
publication

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division

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01 Apr 2003
publication

Notch signaling: endocytosis makes delta signal better

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05 Feb 2003
publication

Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression

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01 Jan 2003
publication

[Cell polarity and asymmetric division in the peripheral nervous system of Drosophila]

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01 Oct 2002
publication

Binary cell death decision regulated by unequal partitioning of Numb at mitosis

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22 Jan 2002
publication

Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage

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10 Aug 2001
publication

The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila

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01 Aug 2001
publication

Lineage diversity in the Drosophila nervous system

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15 May 2001
publication

Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila

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01 Mar 2001
publication

Lineage, cell polarity and inscuteable function in the peripheral nervous system of the Drosophila embryo

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08 Jan 2001
publication

Wasp, the Drosophila Wiskott-Aldrich syndrome gene homologue, is required for cell fate decisions mediated by Notch signaling

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01 Jan 2001
publication

Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division

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06 Apr 2000
publication

Cell polarity: fixing cell polarity with Pins

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01 Feb 2000
publication

Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies

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01 Feb 2000
publication

Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo

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28 Sep 1999
publication

Dominant-negative mutation in the beta2 and beta6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage

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01 Aug 1999
publication

Revisiting the Drosophila microchaete lineage: a novel intrinsically asymmetric cell division generates a glial cell

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01 Jul 1999
publication

Presenilins in their infancy

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18 Jun 1998
publication

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

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14 May 1998
publication

Frizzled signalling controls orientation of asymmetric sense organ precursor cell divisions in Drosophila

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01 Mar 1998
publication

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction

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01 Jan 1997
publication

Role of suppressor of hairless in the delta-activated Notch signaling pathway

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01 Jun 1996
publication

Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling

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01 Jan 1996
publication

Control of cell fate choices by lateral signaling in the adult peripheral nervous system of Drosophila melanogaster

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01 Nov 1995
publication

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling

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01 Jun 1995
publication

Suppressor of Hairless is required for signal reception during lateral inhibition in the Drosophila pupal notum

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01 Jan 1995
publication

Evolutionarily conserved positive and negative cis-acting elements control the blastoderm-specific expression of the Drosophila serendipity alpha cellularisation gene

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01 Dec 1994
publication

The sequence similarity of the Drosophila suppressor of hairless protein to the integrase domain has no functional significance in vivo

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15 Oct 1994
publication

Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless

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01 Jun 1994
publication

Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis

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01 Oct 1993
publication

Relationship between expression of serendipity alpha and cellularisation of the Drosophila embryo as revealed by interspecific transformation

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26 Jun 1992
publication

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

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15 Sep 1991
publication

Engineered secreted T-cell receptor alpha beta heterodimers

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01 Jan 1991
publication

Genetic analysis of the cellularization of the Drosophila embryo

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01 Jun 1990
publication

The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo

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01 Nov 1989
publication

cis-regulatory elements of the Drosophila blastoderm-specific serendipity alpha gene: ectopic activation in the embryonic PNS promoted by the deletion of an upstream region

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