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© Research
Publication : Nature cell biology

Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature cell biology - 01 Jan 2001

Bellaïche Y, Gho M, Kaltschmidt JA, Brand AH, Schweisguth F

Link to Pubmed [PMID] – 11146626

Nat. Cell Biol. 2001 Jan;3(1):50-7

Cell-fate diversity is generated in part by the unequal segregation of cell-fate determinants during asymmetric cell divisions. In the Drosophila pupa, the pI sense organ precursor cell is polarized along the anterior-posterior axis of the fly and divides asymmetrically to generate a posterior pIIa cell and an anterior pIIb cell. The anterior pIIb cell specifically inherits the determinant Numb and the adaptor protein Partner of Numb (Pon). By labelling both the Pon crescent and the microtubules in living pupae, we show that determinants localize at the anterior cortex before mitotic-spindle formation, and that the spindle forms with random orientation and rotates to line up with the Pon crescent. By imaging living frizzled (fz) mutant pupae we show that Fz regulates the orientation of the polarity axis of pI, the initiation of spindle rotation and the unequal partitioning of determinants. We conclude that Fz participates in establishing the polarity of pI.

https://www.ncbi.nlm.nih.gov/pubmed/11146626