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© Research
Event

SEMINAR “Design principles of cell-cell signaling processes” by David Sprinzak

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
24
Mar 2017
Time
12:00:00
25 Rue du Docteur Roux, Paris, France
Address
Building: (#66) Room: Amphithéatre Jacques Monod
Location
2017-03-24 12:00:00 2017-03-24 13:15:00 Europe/Paris SEMINAR “Design principles of cell-cell signaling processes” by David Sprinzak Department of Developmental and Stem Cell Biology 2017 Seminar Series Friday 24th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66) SEMINAR ” Design principles of cell-cell signaling processes “ Invited Speaker ⇒ […] 25 Rue du Docteur Roux, Paris, France François Schweisguth francois.schweisguth@pasteur.fr

About

Department of Developmental and Stem Cell Biology

2017 Seminar Series

Friday 24th March — at 12.00 pm @ Amphi Jacques Monod (Bât.66)

SEMINAR ” Design principles of cell-cell signaling processes

Invited Speaker David Sprinzak

The Center for Nanoscience & Nanotechnology
Department of Biochemistry and Molecular Biology, Tel Aviv Univ. – Israel

Abstract : During development, cells coordinate their cellular states with their neighbors using a variety of intercellular signaling systems. How each signaling system is optimized to perform its unique function during development is one of the main questions in modern developmental biology. We use a combination of synthetic biology, quantitative live cell imaging, and mathematical modeling to elucidate some of the design principles underlying two major juxtacrine signaling pathways: Notch signaling, used to coordinate differentiation between neighboring cells, and Fat-Dachsous signaling, used for coordination of planar cell polarity in epithelial layers. The first part of the talk will focus on how the interplay between Notch signaling and cellular morphology can affect developmental patterning processes. In the second part of the talk, I will describe how localized feedbacks between Fat4-Dachsous1 complexes on the boundary between cells underlie the emergence of planar cell polarity. I will emphasize the link between molecular properties of the signaling molecules and their role in coordinating organization across the whole tissue.

Hosted by François Schweisguth

Location

Building: (#66)
Room: Amphithéatre Jacques Monod
Address: 25 Rue du Docteur Roux, Paris, France