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© Research
Publication : BioEssays : news and reviews in molecular, cellular and developmental biology

Cell Polarity and Notch Signaling: Linked by the E3 Ubiquitin Ligase Neuralized?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BioEssays : news and reviews in molecular, cellular and developmental biology - 21 Sep 2017

Perez-Mockus G, Schweisguth F

Link to Pubmed [PMID] – 28940548

Bioessays 2017 Nov;39(11)

Notch is a mechanosensitive receptor that requires direct cell-cell contact for its activation. Both the strength and the range of notch signaling depend on the size and geometry of the contact sites between cells. These properties of cell-cell contacts in turn depend on cell shape and polarity. At the molecular level, the E3 ubiquitin ligase Neuralized (Neur) links receptor activation with epithelial cell remodeling. Neur regulates the endocytosis of the Notch ligand Delta (Dl), hence Notch activation. It also targets the apical polarity protein Stardust (Sdt) to promote the endocytosis of the Crumbs complex, thereby contributing to epithelium remodeling. Here, we review the interplay between Notch signaling and cell polarity and discuss the possible significance of linking Notch signaling with epithelial cell polarity via a common regulator.