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© Research
Publication : Development (Cambridge, England)

Transcriptional control of stem cell maintenance in the Drosophila intestine

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Development (Cambridge, England) - 01 Mar 2010

Bardin AJ, Perdigoto CN, Southall TD, Brand AH, Schweisguth F

Link to Pubmed [PMID] – 20147375

Development 2010 Mar;137(5):705-14

Adult stem cells maintain tissue homeostasis by controlling the proper balance of stem cell self-renewal and differentiation. The adult midgut of Drosophila contains multipotent intestinal stem cells (ISCs) that self-renew and produce differentiated progeny. Control of ISC identity and maintenance is poorly understood. Here we find that transcriptional repression of Notch target genes by a Hairless-Suppressor of Hairless complex is required for ISC maintenance, and identify genes of the Enhancer of split complex [E(spl)-C] as the major targets of this repression. In addition, we find that the bHLH transcription factor Daughterless is essential to maintain ISC identity and that bHLH binding sites promote ISC-specific enhancer activity. We propose that Daughterless-dependent bHLH activity is important for the ISC fate and that E(spl)-C factors inhibit this activity to promote differentiation.

http://www.ncbi.nlm.nih.gov/pubmed/20147375