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© Research
Publication : PloS one

Insensible is a novel nuclear inhibitor of Notch activity in Drosophila

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 05 Jun 2014

Coumailleau F, Schweisguth F

Link to Pubmed [PMID] – 24902027

PLoS ONE 2014;9(6):e98213

Notch signalling regulates a wide range of developmental processes. In the Drosophila peripheral nervous system, Notch regulates a series of binary fate decisions that lead to the formation of regularly spaced sensory organs. Each sensory organ is generated by single sensory organ precursor cell (SOP) via a series of asymmetric cell divisions. Starting from a SOP-specific Cis-Regulatory Module (CRM), we identified insensible (insb), a.k.a CG6520, as a SOP/neuron-specific gene encoding a nuclear factor that inhibits Notch signalling activity. First, over-expression of Insb led to the transcriptional repression of a Notch reporter and to phenotypes associated with the inhibition of Notch. Second, while the complete loss of insb activity had no significant phenotype, it enhanced the bristle phenotype associated with reduced levels of Hairless, a nuclear protein acting as a co-repressor for Suppressor of Hairless. In conclusion, our work identified Insb as a novel SOP/neuron-specific nuclear inhibitor of Notch activity in Drosophila. http://www.ncbi.nlm.nih.gov/pubmed/24902027