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© Research
Publication : Development genes and evolution

The activity of Drosophila Hairless is required in pupae but not in embryos to inhibit Notch signal transduction

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Development genes and evolution - 01 Mar 1998

Schweisguth F, Lecourtois M

Link to Pubmed [PMID] – 9518521

Dev. Genes Evol. 1998 Mar;208(1):19-27

Drosophila Hairless (H) encodes a negative regulator of Notch signalling. H activity antagonizes Notch (N) signalling during bristle development at the pupal stage. We show here by clonal analysis that H acts by inhibiting signal transduction rather than by promoting signal production, during both selection of microchaete precursors in the notum and vein cell differentiation in the wing. Allele-specific interactions further suggest that H inhibits Notch signal transduction by interacting directly with Suppressor of Hairless. Unexpectedly, this regulatory function of H appears to be essential only during imaginal development. Using a null allele of H that corresponds to a deletion of the H coding sequence, we show that embryos devoid of both maternal and zygotic gene products develop similarly to wild-type embryos. Thus, H activity is not strictly required to regulate N-mediated cell fate choices in the embryo.

https://www.ncbi.nlm.nih.gov/pubmed/9518521