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© Research
Publication : Nature cell biology

Endocytosis by Numb breaks Notch symmetry at cytokinesis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature cell biology - 22 Jan 2012

Couturier L, Vodovar N, Schweisguth F

Link to Pubmed [PMID] – 22267085

Nat. Cell Biol. 2012 Feb;14(2):131-9

Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not inherit Numb. Numb and Sanpodo act together to regulate Notch trafficking and establish directional Notch signalling at cytokinesis. We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice.

http://www.ncbi.nlm.nih.gov/pubmed/22267085