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© Research
Publication : Current biology : CB

Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current biology : CB - 22 Jan 2002

Le Borgne R, Bellaïche Y, Schweisguth F

Link to Pubmed [PMID] – 11818059

Curr. Biol. 2002 Jan;12(2):95-104

Generation of cell-fate diversity in Metazoan depends in part on asymmetric cell divisions in which cell-fate determinants are asymmetrically distributed in the mother cell and unequally partitioned between daughter cells. The polarization of the mother cell is a prerequisite to the unequal segregation of cell-fate determinants. In the Drosophila bristle lineage, two distinct mechanisms are known to define the axis of polarity of the pI and pIIb cells. Frizzled (Fz) signaling regulates the planar orientation of the pI division, while Inscuteable (Insc) directs the apical-basal polarity of the pIIb cell. The orientation of the asymmetric division of the pIIa cell is identical to the one of its mother cell, the pI cell, but, in contrast, is regulated by an unknown Insc- and Fz-independent mechanism.

http://www.ncbi.nlm.nih.gov/pubmed/11818059