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© Research
Publication : PloS one

Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 13 Feb 2009

Gomes JE, Corado M, Schweisguth F

Link to Pubmed [PMID] – 19214234

PLoS ONE 2009;4(2):e4485

Drosophila sensory organ precursor cells (SOPs) divide asymmetrically along the anterior-posterior (a-p) body axis to generate two different daughter cells. Planar Cell Polarity (PCP) regulates the a-p orientation of the SOP division. The localization of the PCP proteins Van Gogh (Vang) and Frizzled (Fz) define anterior and posterior apical membrane domains prior to SOP division. Here, we investigate the relative contributions of Vang, Fz and Dishevelled (Dsh), a membrane-associated protein acting downstream of Fz, in orienting SOP polarity. Genetic and live imaging analyses suggest that Dsh restricts the localization of a centrosome-attracting activity to the anterior cortex and that Vang is a target of Dsh in this process. Using a clone border assay, we provide evidence that the Vang and fz genes act redundantly in SOPs to orient its polarity axis in response to extrinsic local PCP cues. Additionally, we find that the activity of Vang is dispensable for the non-autonomous polarizing activity of fz. These observations indicate that both Vang and Fz act as cues for downstream effectors orienting the planar polarity axis of dividing SOPs.

http://www.ncbi.nlm.nih.gov/pubmed/19214234