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© Research
Publication : Developmental dynamics : an official publication of the American Association of Anatomists

Glycosphingolipids in signaling and development: from liposomes to model organisms

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developmental dynamics : an official publication of the American Association of Anatomists - 28 Oct 2011

Pontier SM, Schweisguth F

Link to Pubmed [PMID] – 22038940

Dev. Dyn. 2012 Jan;241(1):92-106

Since the launch of the raft hypothesis in 1997, data generated in liposomes and cultured cells have highlighted the role of glycosphingolipids (GSLs) in the dynamic organization of biological membranes and the activity of signaling complexes. In parallel studies, genetic analysis of the GSL synthetic pathway has begun to reveal some of the specific roles of GSLs in vivo. Here, we review the role of GSLs in signaling in the context of a refined raft hypothesis. Recent genetic studies in worms, flies, and mice give us the opportunity to integrate these in vivo data with earlier in vitro liposome studies.

http://www.ncbi.nlm.nih.gov/pubmed/22038940