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© Research
Publication : Current biology : CB

Notch signalling: receptor cis-inhibition to achieve directionality

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current biology : CB - 25 Aug 2009

del Alamo D, Schweisguth F

Link to Pubmed [PMID] – 19706274

Curr. Biol. 2009 Aug;19(16):R683-4

Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells. New evidence suggests that cis-inhibition of the receptor in the ligand-sending cell might also provide directionality.