Welcome to the web site of the Trypanosome Cell Biology Unit (TRYPA)!
Our lab is studying the role and the functioning of the trypanosome flagellum, with perspectives in the field of both parasitology and genetic diseases.
Indeed, trypanosomes are significant parasites of man and cattle in central Africa and there are currently no efficient vaccines against them. Moreover, trypanosomes are also an excellent model to study human genetic diseases due to defects in cilia and flagella.
Our lab is a Pasteur full research unit and is affiliated to the Department of Parasites and Insect Vectors (headed by Ken Vernick) but also to the Department of Cell Biology and Infection (headed by Chiara Zurzolo). We also belong to a larger INSERM unit (U1201, headed by Artur Scherf) that involves two other teams working on Plasmodium and on Leishmania. We are also part of the LabEx IBEID, a consortium coordinated by Professors Philippe Sansonetti and Pascale Cossart whose aim is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs).
Finally, we are labelled as “équipe FRM” (Fondation pour la Recherche Médicale)
We live on the first floor of the Nicolle building but are travelling regularly through the multiple platforms of the campus.
27th September. Cécile’s viva took place on Tuesday. “The paths of intraflagellar transport” convinced the jury and she is now Dr. Fort. Congratulations!
22th September. Brice and Christelle’s paper demonstrating the importance of trypanosome presence in the skin is published in eLife.
22th July. The whole lab participated to “Roulez solidaires” where we cycled to raise funding for the Institut Pasteur.
29th June. Sadly Keith Vickerman died last night. Keith was a precursor in protist biology and the first one to link morphogical and molecular biology studies. He gave an inspiring talk in Pasteur in the Trypanosome Flagellum Meeting in 2006 (photo below).
26th June. Cécile’s paper demonstrating the role of IFT in flagellum maintenance is published. Click here for connexion to the publisher site.
10-12th May. We had a vibrant lab retreat in La Rochelle, where everybody gave a talk leading to stimulating discussions and plenty of new ideas!
OTHER NEWS: see bottom of the page
VIDEO: Click here for a general presentation of sleeping sickness (in French)