Welcome to the web site of the Trypanosome Cell Biology Unit (TRYPA)!
Our lab is studying the role and the functioning of the trypanosome flagellum, with perspectives in the field of both parasitology and genetic diseases.
Indeed, trypanosomes are significant parasites of man and cattle in central Africa and there are currently no efficient vaccines against them. Moreover, trypanosomes are also an excellent model to study human genetic diseases due to defects in cilia and flagella.
Our lab is an international mixture with 7 nationalities and expertise in parasitology and cell biology. We are a Pasteur full research unit and are affiliated to the Department of Parasites and Insect Vectors (headed by Gerald Spaeth) but also to the Department of Cell Biology and Infection (headed by Chiara Zurzolo). We belong to an INSERM unit (U1201, headed by Artur Scherf) that involves two other teams working on Plasmodium and on Leishmania. We are also part of the LabEx IBEID, a consortium coordinated by Professors Philippe Sansonetti and Pascale Cossart whose aim is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs).
Finally, we are labelled as “équipe FRM” (Fondation pour la Recherche Médicale)
We live on the first floor of the Nicolle building but are travelling regularly through the multiple platforms of the campus.
VIDEO: Click here for a general presentation of sleeping sickness (in French)
1st December. Our work on IFT25 is now available on BioRxiv.
15th November. The work of Eloïse and Benjamin (former postdoc) describing a new model for flagellum length control has been published in Current Biology (free link until 22nd January 2019). More details can be found on our Twitter account.
2nd November. Serge’s paper on the intriguing ODA8/LRRC56 protein is out in American Journal of Human Genetics. It was a great collaboration with the clinical teams of Eamonn Sheridan and Kym Boycott, made possible thanks to Michel Leroux. More details on our Twitter account.
27th October. We have opened our Twitter account. It can also be reached from the icon above.
16th October. We got a prize for our cycling efforts to raise funding for the Institut Pasteur!
11th October. We had the visit of Professor Liangyi Chen from Peking University. He gave an impressive talk on the recent developments he achieved in super-resolution imaging of live cells. The potential of these approaches for imaging IFT is super-exciting!
10th October. Today was the kick-off meeting for our new project on tubulin polyglutamylation with the units of Julia Chamot-Rooke and Carsten Janke. We already made a lot of progress through a deep brainstorming session!
3rd October. Serge’s paper on the function of LRRC56 in collaboration with Eamonn Sheridan’s group is accepted in American Journal of Human Genetics. It is currently available on line in BioRxiv.
2nd October. The IFT distribution paper is now available on the web site of JCB.
21st September. Our paper on the positioning of IFT in the trypanosome flagellum has been accepted in Journal of Cell Biology! It is currently available on line in bioRxiv.
20th September. Eloïse has completed her thesis defence and is a now a doctor! She had stimulating discussion with the jury composed of cilia, cytoskeleton and trypanosome people. We thank them for the excellent questions and for having stimulated such an exciting debate. Eloïse will stay with us for a short post-doc until the end of the year.
13th July. Great news, our ANR grant to study tubulin glutamylation has been funded!
23rd May 2018. Our work on the identification of two tracks for IFT in the trypanosome flagellum is now available on line in bioRxiv.
12th April. Moara won an award for best poster presentation at the departmental retreat in Maintenon!
27th March. Serge’s work on the intriguing ODA8/LRRC56 is now on line on bioRxiv.
16th February. The work of Eloïse and Benjamin (former postdoc) describing a new model for flagellum length control is now available on bioRxiv.
5th-8th February. We spent three excellent days at Strasbourg for the lab retreat. It is amazing how much work can be done when we focus about it in a tiny cosy room! While Paris was under the snow, we enjoyed dry weather. Unexpected!
2nd February. Thierry’s beautiful image makes the front cover of this month issue of Biology of the Cell!
15th December. Sylvain’s paper describing the structure of the transition zone by STEM has been accepted for publication and can be accessed here. It reveals two domains for the TZ and a more sophisticated organisation of the Y-links than initially thought.
16th November. Laetitia’s paper on incorporation of flagellar proteins is now available on line. It took a while but it is there in the end!
4th October. The symposium Future of Parasitology has been a delight with exceptional presentations from a combination of junior and senior scientists. We dare say the future looks bright!
29th August. Our lab contributes to the organisation of two Parasitology conferences on the campus: the symposium Future of Parasitology and the annual meeting Trypanosomatid parasites: from the field to the lab.
15th May. Eloïse is awarded an FRM fellowship to continue her thesis work on the regulation of flagellum length in trypanosomes.
9th May. Brice is currently in Guinea working on the field whilst Moara and Jamin just got back from the Kinetoplastid Molecular and Cellular Biology Meeting in Woods Hole (USA).
17th March. In collaboration with Sylvain Trépout and Sergio Marco, we published a review on the “Preparation and Observation of Thick Biological Samples by Scanning Transmission Electron Tomography” that is accessible here.
1st March. Arrival of Elise Warter who is starting her Master project on tubulin glutamylation in trypanosome flagella.
1st February. Arrival of Sebastian Hutchinson to develop a new project using microfluidics funded by a Roux post-doctoral fellowship.
9th January. The GDR Cilia, a scientific network headed by Philippe and grouping 35 French labs working on cilia, has been renewed for another 5 year-term! It will allow us to organise conferences and to support students to go to meetings or to visit other labs.
16th December. Cécile got her PhD diploma today at the official ceremony headed by Monica Sala in the presence of the DG Christian Bréchot.
12th December. We are hosting Estelle Kolda, a student of “3ème” for a week, she is here to discover the professional environment of a research lab. She is very enthusiastic!
10th November. Great news with a new LabEx IBEID fellowship for Estefania to continue her work on trypanosome infectivity.
27th September. Cécile’s viva took place on Tuesday. “The paths of intraflagellar transport” convinced the jury and she is now Dr. Fort. Congratulations! She is now doing a postdoc in the UK.
22th September. Brice and Christelle’s paper demonstrating the importance of trypanosome presence in the skin is published in eLife.
22th July. The whole lab participated to “Roulez solidaires” where we cycled to raise funding for the Institut Pasteur.
29th June. Sadly Keith Vickerman died last night. Keith was a precursor in protist biology and the first one to link morphogical and molecular biology studies. He gave an inspiring talk in Pasteur in the Trypanosome Flagellum Meeting in 2006 (photo below).
26th June. Cécile’s paper demonstrating the role of IFT in flagellum maintenance is published. Click here for connexion to the publisher site.
10-12th May. We had a vibrant lab retreat in La Rochelle, where everybody gave a talk leading to stimulating discussions and plenty of new ideas!
OTHER NEWS: see bottom of the page