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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell

About

Welcome to the web site of the Trypanosome Cell Biology Unit (TRYPA)!

Our lab is studying the role and the functioning of the trypanosome flagellum, with perspectives in the field of both parasitology and genetic diseases.

Indeed, trypanosomes are significant parasites of man and cattle in central Africa and there are currently no efficient vaccines against them. Moreover, trypanosomes are also an excellent model to study human genetic diseases due to defects in cilia and flagella.

Our lab is a Pasteur full research unit and is affiliated to the Department of Parasites and Insect Vectors (headed by Ken Vernick) but also to the Department of Cell Biology and Infection (headed by Chiara Zurzolo). We also belong to a larger INSERM unit (U1201, headed by Artur Scherf) that involves two other teams working on Plasmodium and on Leishmania. We are also part of the LabEx IBEID, a consortium coordinated by Professors Philippe Sansonetti and Pascale Cossart whose aim is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs).

Finally, we are labelled as “équipe FRM” (Fondation pour la Recherche Médicale)

We live on the first floor of the Nicolle building but are travelling regularly through the multiple platforms of the campus.

 

LATEST NEWS:

4th October. The symposium Future of Parasitology has been a delight with exceptional presentations from a combination of junior and senior scientists. We dare say the future looks bright!

29th August. Our lab contributes to the organisation of two Parasitology conferences on the campus: the symposium Future of Parasitology and the annual meeting Trypanosomatid parasites: from the field to the lab.

15th May. Eloïse is awarded an FRM fellowship to continue her thesis work on the regulation of flagellum length in trypanosomes.

9th May. Brice is currently in Guinea working on the field whilst Moara and Jamin just got back from the Kinetoplastid Molecular and Cellular Biology Meeting in Woods Hole (USA).

17th March. In collaboration with Sylvain Trépout and Sergio Marco, we published a review on the “Preparation and Observation of Thick Biological Samples by Scanning Transmission Electron Tomography” that is accessible here.

1st March. Arrival of Elise Warter who is starting her Master project on tubulin glutamylation in trypanosome flagella.

1st February. Arrival of Sebastian Hutchinson to develop a new project using microfluidics funded by a Roux post-doctoral fellowship.

9th January. The GDR Cilia, a scientific network headed by Philippe and grouping 35 French labs working on cilia, has been renewed for another 5 year-term! It will allow us to organise conferences and to support students to go to meetings or to visit other labs.

16th December. Cécile got her PhD diploma today at the official ceremony headed by Monica Sala in the presence of the DG Christian Bréchot.

12th December. We are hosting Estelle Kolda, a student of “3ème” for a week, she is here to discover the professional environment of a research lab. She is very enthusiastic!

10th November. Great news with a new LabEx IBEID fellowship for Estefania to continue her work on trypanosome infectivity.

27th September. Cécile’s viva took place on Tuesday. “The paths of intraflagellar transport” convinced the jury and she is now Dr. Fort. Congratulations! She is now doing a postdoc in the UK.

22th September. Brice and Christelle’s paper demonstrating the importance of trypanosome presence in the skin is published in eLife.

Click here for the Press release

22th July. The whole lab participated to “Roulez solidaires” where we cycled to raise funding for the Institut Pasteur.

Group_cycling

 

29th June. Sadly Keith Vickerman died last night. Keith was a precursor in protist biology and the first one to link morphogical and molecular biology studies. He gave an inspiring talk in Pasteur in the Trypanosome Flagellum Meeting in 2006 (photo below).

Vickerman

26th June. Cécile’s paper demonstrating the role of IFT in flagellum maintenance is published. Click here for connexion to the publisher site.

10-12th May. We had a vibrant lab retreat in La Rochelle, where everybody gave a talk leading to stimulating discussions and plenty of new ideas!

 

OTHER NEWS: see bottom of the page

VIDEO: Click here for a general presentation of sleeping sickness (in French)

 

 

Projects

Transversal Project

Fundings

Publications

TRYPA news

 

Trypa_LaRochelle_01_small

Dernières nouvelles

10 mars. Félicitations à Brice qui a défendu avec succès son HDR aujourd’hui !

29 Janvier. Petite fête au labo à l’occasion du dernier jour de Sylvie. Elle va nous manquer (et probablement aussi aux mouches).Cropped_IMG_8288

1 février. Arrivée de Moara Lemos qui va étudier comment les moteurs interagissent avec les microtubules et les complexes IFT.

29 janvier. Départ de Sylvie qui déménage en Bourgogne pour raisons familiales après plus de 30 ans de bons et loyaux services !

14th October: Félicitations à Eloïse qui a remporté un des deux prix pour la meilleure présentation orale au 9th Cilia, Flagella and Centrosomes meeting à Strasbourg !

9th October: Nous combattons les virus au Pasteurdon! Grâce à la générosité des donateurs,  1.2 Mo € de promesses de dons ont été faites en faveur de l’Institut Pasteur.

Capture d’écran 2015-10-09 à 22.40.22 Capture d’écran 2015-10-09 à 22.42.34

1st October: Bienvenue à Jamin Jung qui démarre son postdoc avec nous pour étudier le rôle d’ IFT172 en collaboration avec l’équipe d’Esben Lorentzen au MPI.