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  • program_project
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  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
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  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Oct 2018
Ending Date
30
Sep 2022
Status
Ongoing
Members
2
Structures
7

About

Trypanosoma brucei gambiense causes chronic Human African Trypanosomiasis. These extra-cellular protist parasites are transmitted by tsetse flies and proliferate in the host blood. We have recently demonstrated that the skin was a major yet overlooked anatomical reservoir for trypanosomes that may thwart control programs. This project aims at understanding the biological significance of skin parasites, especially how they impact our current view of transmission, diagnosis and treatment. We will (1) unravel the development of skin-dwelling parasites (differentiation, proliferation, migration), (2) study host/parasites interactions (sequestration, skin remodelling) and (3) further translate these results into applications (prevalence, treatment efficacy and new detection methods). Overall, this multi-disciplinary project will greatly increase our understanding of trypanosome biology in a yet unexplored compartment, and will be determinant for the possible HAT elimination.

 

Left: Trypanosomes (Trypanosoma brucei brucei, fluorescent green) in the dermis of a mouse with no parasites in the bloodstream, 29 days after infection. Right: A trypanosome (Trypanosoma brucei gambiense, the purple cell indicated by a black arrow) in the dermis of an asymptomatic individual living in an endemic area in the Democratic Republic of Congo. From Capewell et al. eLife 2016.

 

In collaboration with: IRD-CIRAD InterTryp (Montpellier), Wellcome Trust (Glasgow), HAT-NCP (Conakry), Institut Pierre Richet (Bouaké) & Université Jean Lorougnon Guédé (Daloa)

Primary funding: ANR PRC 2018 TrypaDerm

Secondary funding: Wellcome Trust & Bill (MacLeod Lab) and Melinda Gates Foundation (TrypaNo!)

Fundings