Cell and molecular biologist with expertise in a protein complex called TRAPP. Having earned a Ph.D. in cell and molecular biology from Concordia University (Montreal – Canada) in 2023, Hashem focused on characterizing TRAPPC10 and TRAPPC6B genes within the complex. His research involved investigating the molecular and cellular consequences of mutations using advanced techniques like CRISPR-Cas9, proximity labeling, yeast genetics, immunofluorescence, and live cell microscopy. Through these methods, he successfully identified functional links between new TRAPP gene variants and cellular trafficking machinery, particularly in relation to neurodevelopmental disorders.
Prior to his Ph.D., Hashem completed an MSc in Biological Science, specializing in cancer genetics, and holds a BSc in Biotechnology and Genetic Engineering.
As a post-doctoral fellow, he has now embarked on investigating IFT139 role in IFT trafficking and flagellum assembly, as well as exploring the impact of IFT139 variants in human patients.