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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Starting Date
01
Oct 2018
Ending Date
30
Sep 2022
Status
Ongoing
Members
10
Structures
4

About

Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act as a tubulin code defining the molecular identity of each microtubule and governing its interactions with associated proteins. This project aims at investigating in detail this particular tubulin code, its biological significance and the way the cells can read it using the protist Trypanosoma brucei as model. First, the complexity of tubulin glutamylation of flagellar microtubules will be deciphered to an unprecedented level using advanced mass spectrometry. Second, the importance of glutamylation will be worked out by either replacement of glutamylases with enzymatically inactive versions or targeted expression of deglutamylases in the flagellum. Finally, the ability of molecular motors to read the tubulin code will be investigated using novel in vitro assays.

Fundings