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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2018
Ending Date
31
Dec 2019
Status
Ongoing
Members
3
Structures
4
Instituts
2

About

We propose to focus on deciphering the mechanistic underpinnings of intracellular replication, as a prominent source of pathogenesis. In particular, given its fundamental role in orchestrating central events to apicomplexan cell division, and flagellar assembly during sexual differentiation, we propose to focus on characterizing the apicomplexan centrosome. Recent findings suggest that apicomplexan centrioles are composed of a mixture of conserved and unique proteins. The latter remain largely unexplored and represent a possible rich source of drugable targets.
This project will be carried out in collaboration among three laboratories (Francia, Gissot and Bastin) with complementary technical and scientific expertise. The Francia laboratory at the Institut Pasteur Montevideo will perform molecular biology and genetic manipulation of T. gondii, generating the parasite cell lines necessary for launching this project. Maria Eugenia Francia is the PI of the project. The Gissot laboratory at the Institut Pasteur in Lille has extensive expertise on proteome and phospho-proteome analysis, invaluable skills for the advancement of this project. Finally, the Bastin Laboratory at the Institut Pasteur Paris has unparalleled knowledge on centrosome biology and experience in the use of advanced microscopy techniques such as super-resolution, photo-bleaching and electron microscopy to
approach flagellar biology related questions. These skills will be extensively exploited for the completion of this project.

 

Fundings