Genetic traits involved in the regulation of NK cell and ILC-mediated anti-tumor functions
Rudolf Virchow postulated more than 150 years ago that inflammation might be linked to cancer development. Although a large body of experimental evidence accumulated to date strongly supports such a link, it is less […]
Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]
Mouse Model to Understand Innate Lymphoid Cell Biology
Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]
2022Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation., Nat Commun 2022 Jul; 13(1): 4344.
2021Dichotomous metabolic networks govern human ILC2 proliferation and function., Nat Immunol 2021 Oct; 22(11):1367-1374.
2021Host genetic control of natural killer cell diversity revealed in the Collaborative Cross., Proc Natl Acad Sci U S A 2021 03; 118(10): .
2021Polarized mitochondria as guardians of NK cell fitness., Blood Adv 2021 01; 5(1): 26-38.
2016Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells, J. Immunol. 2016 Jun;196(11):4731-8.