Laboratoire

Immunité innée

Responsable

James Di Santo

Inserm U1223

Département de Immunologie

• Anticancer immunity
• Biological basis of immunity related disorders
• Development of immune system
• Immunology
• Innate immunity
• Mucosal immunity
• Vaccinology
• AIDS
• Chronic infection
• Hepatitis B
• Immune disorders
• Immunodeficiency
• Names of infectious diseases
• Virus diseases
• Model systems
• Mouse

VOIR TOUSFermer

Présentation

Désolé, cet article est seulement disponible en Anglais Américain.

Groupes

Group

Hélène Strick-Marchand

Groupe: Modèles murins pour les pathologies infectieuses humaines

Group

Christian Vosshenrich

Groupe: Biologie des Cellules NK et ILC1

Membres

James Di Santo

Responsable de Structure

Responsable

Hélène Strick-Marchand

Chef(fe) de Groupe

Christian Vosshenrich

Chef(fe) de Groupe

Nicolas Serafini

Chercheur(euse) Permanent(e)

Giorgia Benigni

Post-doctorant(e)

Jean-Marc Doisne

Post-doctorant(e)

Pedro Goncalves

Post-doctorant(e)

Yan Li

Post-doctorant(e)

Guillemette Masse-Ranson

Post-doctorant(e)

Laura Surace

Post-doctorant(e)

Silvia Lopez Lastra

Etudiant(e) en thèse

Ai Ing Lim

Etudiant(e) en thèse

Thomas Verrier

Etudiant(e) en thèse

Dylan Cherrier

Etudiant(e) en thèse

Marie Solenne

Ingénieur(e) de Recherche

Angèle Schiavo

Technicien(ne)

Cécile Pham

Personnel Administratif

Anciens Membres

Erwan Corcuff

Georges Azar

Abdessalem Rekiki

Milena Hasan

Wei Xu

Sylvie Darche

Grands Projets

Ebola task force

http://ebolataskforce.org/

Milieu Intérieur [LabEx]

Qu’est-ce que le projet Milieu Intérieur ?Le projet Milieu Intérieur est l’un des lauréats de la première vague d’appel d’offre “Laboratoire d’Excellence”. Le projet Milieu Intérieur réunit l’expertise multidisciplinaire de chercheurs dans les domaines […]

LabEx Revive – Biologie régénératrice et médicine

  Objectifs du Consortium ReviveDes avancées scientifiques majeures dans la biologie des cellules souches ont ouvert la voie à des activités de recherche sur la biologie fondamentale de ces cellules et leurs applications cliniques. Le […]

Projets

ERC-2015-AdG ILC_REACTIVITY

Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α […]

Adult neurogenesis and brain plasticity

The phenomenon of neurogenesis in adult animals, which has therapeutic potential in treating neurodegenerative diseases, leads to several questions: What controls the pattern of connections formed by new cells? How is the stability of […]

Thematic Interest Group: Mucosal Immunology

The TIG Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It is […]

Innate Lymphoid Cells in Immune Responses

Mucosal homeostasis requires a delicate equilibrium between immune mechanisms and commensal microorganisms that impacts on the development and maintenance of critical physiological processes including digestion, metabolism or host defense. Several infectious or inflammatory disorders […]

Pathogen co-infection : HIV, TB, Malaria and HCV

Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]

Host responses to microbial intestinal invasion, impact on microbial dissemination

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]

A novel mouse model for conditional gene targeting

Research in the Innate Immunity Unit strives to understand the signals that regulate lymphoid lineage development and the mechanisms that promote the functional diversification of lymphocyte responses. Modeling Hepatitis B virus infections in a […]

Financements

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Publications

• 2016
  Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells - Pallett MA, Crepin VF, Serafini N, Habibzay M, Kotik O, Sanchez-Garrido J, Di Santo JP, Shenoy AR, Berger CN, Frankel G - Mucosal immunology
• 2016
  Interleukin 15-Dependent T Cell-like Innate Intraepithelial Lymphocytes Develop in the Intestine and Transform into Lymphomas in Celiac Disease - Ettersperger J, Montcuquet N, Malamut G, Guegan N, Lopez-Lastra S, Gayraud S, Reimann C, Vidal E, Cagnard N, Villarese P, Andre-Schmutz I, Gomes Domingues R, Godinho-Silva C, Veiga-Fernandes H, Lhermitte L, Asnafi V, Macintyre E, Cellier C, Beldjord K, Di Santo JP, Cerf-Bensussan N, Meresse B - Immunity
• 2016
  Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses - Urrutia A, Duffy D, Rouilly V, Posseme C, Djebali R, Illanes G, Libri V, Albaud B, Gentien D, Piasecka B, Hasan M, Fontes M, Quintana-Murci L, Albert ML, - Cell reports
• 2016
  The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome - Gury-BenAri M, Thaiss CA, Serafini N, Winter DR, Giladi A, Lara-Astiaso D, Levy M, Salame TM, Weiner A, David E, Shapiro H, Dori-Bachash M, Pevsner-Fischer M, Lorenzo-Vivas E, Keren-Shaul H, Paul F, Harmelin A, Eberl G, Itzkovitz S, Tanay A, Di Santo JP, Elinav E, Amit I - Cell
• 2016
  Notch signaling in group 3 innate lymphoid cells modulates their plasticity - Chea S, Perchet T, Petit M, Verrier T, Guy-Grand D, Banchi EG, Vosshenrich CA, Di Santo JP, Cumano A, Golub R - Science signaling
• 2016
  Thymocytes self-renewal: A major hope or a major threat? - Peaudecerf L, Krenn G, Gonçalves P, Vasseur F, Rocha B - Immunol Rev.
• 2016
  Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells - Verrier T, Satoh-Takayama N, Serafini N, Marie S, Di Santo JP, Vosshenrich CA - Journal of immunology (Baltimore, Md. : 1950)
• 2016
  An Intestinal Inflammasome – The ILC3-Cytokine Tango. - Gonçalves P, Di Santo JP - Trends Mol Med.
• 2016
  IL-12 drives functional plasticity of human group 2 innate lymphoid cells - Lim AI, Menegatti S, Bustamante J, Le Bourhis L, Allez M, Rogge L, Casanova JL, Yssel H, Di Santo JP - The Journal of experimental medicine
• 2016
  An Intestinal Inflammasome – The ILC3-Cytokine Tango - Gonçalves P, Di Santo JP - Trends in molecular medicine
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  Voir la liste complète de publications

Contact

Phone: 0145688696
Email: james.di-santo@pasteur.fr

Address
25-28 Rue du Docteur Roux