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Pathogen co-infection : HIV, TB, Malaria and HCV
James Di Santo (PI)
Acquired immune deficiency syndrome (AIDS), tuberculosis (TB) and malaria are the primary infectious diseases causing death world wide. TB is responsible for a third to a half of human immunodeficiency virus type 1 (HIV-1)–associated […]
Humanized mouse models for studying viral hepatitis
Hélène Strick-Marchand (PI)
Hepatitis B virus (HBV), hepatitis C virus (HCV) and Plasmodium falciparum are three major human hepatic pathogens, which together are responsible for more than 500 million infections worldwide and 2.5 to 4.5 million deaths […]
2020In-vitro and in-vivo models for hepatitis B cure research, Curr Opin HIV AIDS 2020 Feb;.
2019Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses and in Humanized Mice, Antimicrob. Agents Chemother. 2020 01;64(2).
2019Accelerated thymopoiesis and improved T cell responses in HLA-A2/-DR2 transgenic BRGS-based human immune system mice, Eur. J. Immunol. 2019 Mar;.
2018Who Defends the Stem Cell’s Citadel?, Cell Stem Cell 2018 Mar;22(3):287-289.
2017Regulatory T cells control toxicity in a humanized model of IL-2 therapy, Nat Commun 2017 11;8(1):1762.
2017Modeling hepatitis virus infections and treatment strategies in humanized mice, Curr Opin Virol 2017 Aug;25:119-125.
2017Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver, Gastroenterology 2017 12;153(6):1647-1661.e9.
2017A functional DC cross talk promotes human ILC homeostasis in humanized mice, Blood Adv 2017 Apr;1(10):601-614.
2017Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation, Cell 2017 03;168(6):1086-1100.e10.
2016A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development, Eur. J. Immunol. 2016 May;46(5):1291-9.
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