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© A. Chauhan, JM Ghigo, C. Beloin.
Biofilm formation by Pseudomonas aeruginosa bacteria in Central Venous Catheter. Bacteria are stained in yellow and blood cells in red.
Scientific Fields
Diseases
Organisms
Applications
Technique

Courses

03:00
01
Sep 2015
Course

Microbiology Course Institut Pasteur

I have been appointed in 2010 then Co-director together with Dr Françoise Norel-Bozouklian in 2014 of this Microbiology course. This nine-week theorical and practical course presents the latest advances in molecular and cellular microbiology. […]
Françoise Norel-Bozouklian
Ingrid Guilvout
Hervé Waxin
Christophe Beloin
2015-09-01 03:00:00 2015-10-30 Europe/Paris Microbiology Course Institut Pasteur I have been appointed in 2010 then Co-director together with Dr Françoise Norel-Bozouklian in 2014 of this Microbiology course. This nine-week theorical and practical course presents the latest advances in molecular and cellular microbiology. […] 28 Rue du Docteur Roux, Paris, France
14:40
01
Sep 2015
Course

Institut Pasteur Microbiology Course

Françoise Norel has been appointed Co-director of the Institut Pasteur Microbiology Course in 2014. This course is held annually and is part of master trainings proposed by 3 universities: Pierre and Marie Curie (Paris […]
Françoise Norel-Bozouklian
Christophe Beloin
Ingrid Guilvout
Hervé Waxin
2015-09-01 14:40:17 2015-10-30 Europe/Paris Institut Pasteur Microbiology Course Françoise Norel has been appointed Co-director of the Institut Pasteur Microbiology Course in 2014. This course is held annually and is part of master trainings proposed by 3 universities: Pierre and Marie Curie (Paris […] 28 Rue du Docteur Roux, Paris, France

Projects

project
Ongoing
5 Members

ANR Fir-OM: Firmicutes with an outer membrane: toward new models to study the diderm/monoderm cell envelope transition

Simonetta Gribaldo (PI)

The bacterial envelope is one of the oldest and most essential cellular components, being involved in key housekeeping functions, such as physical integrity, cell division, motility, substrate uptake and secretion, and cell-cell communication. It […]
project
Ongoing
4 Members

PTR OmNega: A multi-disciplinary investigation of the Negativicutes: atypical Firmicutes with LPS-outer membranes that inhabit the human gut

Simonetta Gribaldo (PI)

The Negativicutes are a poorly studied lineage of bacteria that include common inhabitants of the human oral and gut microbiome such as the anaerobe Veillonella, and which can also develop into opportunistic pathogens. Despite […]
project
Ongoing
9 Members

Biofilm formation

Christophe Beloin (PI)

Commensal and pathogenic bacteria such as Escherichia coli produce various surface structures promoting their interaction with living or inert surfaces. We study the structure and regulation of E. coli adhesins and extracellular matrix polysaccharides contributing to biofilm […]
project
Ongoing
10 Members

Biofilm physiology

Jean-Marc Ghigo (PI)

  Specific metabolic changes occurring during biofilm formation were hypothesized to lead to the production of biofilm-associated molecules and biofilm-specific functions. The  identification of biofilm-specific metabolites could reveal new aspects of biofilm biology, and lead to novel strategies […]
project
Ongoing
4 Members

Biofilm Tolerance to Antibiotics

Christophe Beloin (PI)

 One of the  of the hallmarks of biofilm physiology is its tolerance to a high level of antimicrobials. We are currently investigating the molecular mechanisms that lead to this transient ability to withstand antimicrobial treatments. […]
project
Ongoing
5 Members

Fighting biofilms

Christophe Beloin (PI)

 Biofilm formation on medical devices is associated with hospital-acquired (nosocomial) infections. Due to biofilms’ high tolerance to antibiotics, classical treatments lack efficacy, and removal of the biofilm-contaminated device is often the only therapeutic option. […]
project
Ongoing
3 Members

Biophysics of Bacteria-Surface Interactions

Christophe Beloin (PI)

Biofilm formation relies as much on bacterial adhesion properties than on surface chemistry, and many questions remain regarding biophysics of surface adhesion. In collaboration with physico-chemists and biophysicists, we used multidisciplinary approaches to investigate bacterial […]

Tools

tool
Ongoing
2 Members

Genetic Methods and Tools

Jean-Marc Ghigo (PI)

We originally developed genetic tools to study adhesion and biofilm formation in commensal and pathogenic E. coli species. These tools are made freely available to the scientific community upon request. • pKOBEG Lambda Red […]
tool
Ongoing
4 Members

In vivo Study of Biofilm-Associated Catheter Infections

Christophe Beloin (PI)

We developed a clinically relevant in vivo model of catheter-associated biofilm infections to design new and efficient biofilm-eradication approaches applicable to contaminated totally implantable venous access port (TIVAP) catheters.      Key publications •  Chauhan, A., J.M. […]
tool
Ongoing
3 Members

Biofilm Microfermenters

Jean-Marc Ghigo (PI)

We designed a continuous-flow culture system in which biofilm formation can be reproducibly monitored and controlled in microfermentors handled at flow-rates avoiding accumulation of planktonic bacteria. This model is suited for biofilm macroscopic analysis, […]

CV

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 I prepared my PhD in the laboratory of Structure and Expression of Bacterial Genome directed by Dr. Françoise Le Hégarat at the University Paris XI where I studied histone-like proteins of the Gram positive bacteria Bacillus subtilis. I obtained my PhD in 1998. The same year I joined the laboratory of Prof. Charles J. Dorman in Trinity College Dublin as a European Post-doctoral fellow. During these three years my research has been focused on the regulation of virulence gene expression in the pathogenic bacteria Shigella flexneri. In 2001, I came back to France on a postdoctoral proposition in the 5 years group recently created by Dr. Jean-Marc Ghigo. I participated to the implementation of the G5 Genetics of Biofilms Laboratory. In 2003, I was recruited at the Institut Pasteur as Assistant Professor (Chargé de Recherche) and have been promoted Associate Professor in 2014. In the  Ghigo’s laboratory, my work  focuses on two biofilm-specific phenomena: initial adhesion to surfaces or between bacteria, which is a key step of any colonization process, and biofilms recalcitrance  towards antibiotic , a major biofilm behavior responsible for chronic and recurrent infections in clinic. Beyond the importance of a better fundamental understanding of the molecular mechanisms controlling these two biofilm-properties , these studies have also been motivated by my desire to translate, when possible, some aspects of my work into clinically relevant situations involving biofilms. Since 2011 I’m strongly involved in teaching at the Institut Pasteur and I have been appointed Co-director of the Institut Pasteur Microbiology Course in 2014.

Publications

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