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Courses
Microbiology Course Institut Pasteur
I have been appointed in 2010 then Co-director together with Dr Françoise Norel-Bozouklian in 2014 of this Microbiology course. This nine-week theorical and practical course presents the latest advances in molecular and cellular microbiology. […]
2015-09-01 03:00:00
2015-10-30
Europe/Paris
Microbiology Course Institut Pasteur
I have been appointed in 2010 then Co-director together with Dr Françoise Norel-Bozouklian in 2014 of this Microbiology course. This nine-week theorical and practical course presents the latest advances in molecular and cellular microbiology. […]
28 Rue du Docteur Roux, Paris, France
Institut Pasteur Microbiology Course
Françoise Norel has been appointed Co-director of the Institut Pasteur Microbiology Course in 2014. This course is held annually and is part of master trainings proposed by 3 universities: Pierre and Marie Curie (Paris […]
2015-09-01 11:21:45
2015-10-30
Europe/Paris
Institut Pasteur Microbiology Course
Françoise Norel has been appointed Co-director of the Institut Pasteur Microbiology Course in 2014. This course is held annually and is part of master trainings proposed by 3 universities: Pierre and Marie Curie (Paris […]
28 Rue du Docteur Roux, Paris, France
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CV
I prepared my PhD in the laboratory of Structure and Expression of Bacterial Genome directed by Dr. Françoise Le Hégarat at the University Paris XI where I studied histone-like proteins of the Gram positive bacteria Bacillus subtilis. I obtained my PhD in 1998. The same year I joined the laboratory of Prof. Charles J. Dorman in Trinity College Dublin as a European Post-doctoral fellow. During these three years my research has been focused on the regulation of virulence gene expression in the pathogenic bacteria Shigella flexneri. In 2001, I came back to France on a postdoctoral proposition in the 5 years group recently created by Dr. Jean-Marc Ghigo. I participated to the implementation of the G5 Genetics of Biofilms Laboratory. In 2003, I was recruited at the Institut Pasteur as Assistant Professor (Chargé de Recherche) and have been promoted Associate Professor in 2014. In the Ghigo’s laboratory, my work focuses on two biofilm-specific phenomena: initial adhesion to surfaces or between bacteria, which is a key step of any colonization process, and biofilms recalcitrance towards antibiotic , a major biofilm behavior responsible for chronic and recurrent infections in clinic. Beyond the importance of a better fundamental understanding of the molecular mechanisms controlling these two biofilm-properties , these studies have also been motivated by my desire to translate, when possible, some aspects of my work into clinically relevant situations involving biofilms. Since 2011 I’m strongly involved in teaching at the Institut Pasteur and I have been appointed Co-director of the Institut Pasteur Microbiology Course in 2014.
Publications
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2022An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition., Nat Microbiol 2022 Mar; 7(3): 411-422.
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2021Lifestyle-specific S-nitrosylation of protein cysteine thiols regulates Escherichia coli biofilm formation and resistance to oxidative stress., NPJ Biofilms Microbiomes 2021 Apr; 7(1): 34.
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2021On the strong connection between nanoscale adhesion of Yad fimbriae and macroscale attachment of Yad-decorated bacteria to glycosylated hydrophobic and hydrophilic surfaces, Nanoscale . 2021 Jan 14;13(2):1257-1272. doi: 10.1039/d0nr06840c. Epub 2021 Jan 6. .
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2021Speciality Grand Challenge for “Biofilms”., Front Cell Infect Microbiol 2021 ; 11(): 632429.
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2020Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition., Nat Ecol Evol 2020 12; 4(12): 1661-1672.
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2020Visualizing the dynamics of exported bacterial proteins with the chemogenetic fluorescent reporter FAST, Sci Rep. 2020 Sep 25;10(1):15791. doi: 10.1038/s41598-020-72498-2. .
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2020Autotransporters drive biofilm formation and auto-aggregation in the diderm Firmicute Veillonella parvula, J Bacteriol . 2020 Aug 17;JB.00461-20. doi: 10.1128/JB.00461-20. Online ahead of print. .
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2020Capsular Polysaccharide Cross-Regulation Modulates Bacteroides thetaiotaomicron Biofilm Formation., mBio 2020 06; 11(3): .
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2020Capsular polysaccharide cross-regulation modulates Bacteroides thetaiotaomicron biofilm formation, mBio May/June 2020 Vol.11(3): e00729-20.
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2020One or two membranes? Diderm Firmicutes challenge the Gram-positive/Gram-negative divide., Mol Microbiol 2020 03; 113(3): 659-671.
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