The outer membrane (OM) is an essential element in Gram-negative (diderm) bacteria. Its integrity is maintained by the control of lipids asymmetry via LPS and phospholipids transport by the Lpt and Mla systems, respectively. […]
Biofilms formed by anaerobes
Although many clinically and ecologically relevant processes are known to be performed by biofilm communities composed of strict or facultative anaerobic bacteria, biofilms were often studied in aerobic conditions. We use in vitro anaerobic culture systems […]
Molecular Bases of Colonization Resistance
We use in vitro and in vivo models of polymicrobial communities in order to better understand the molecular events underlying colonization resistance and pathogen exclusion by commensal bacteria Articles on this topic David Pérez-Pascual, Sol Vendrell-Fernandez, […]
Although competitive interactions between bacteria (bacterial interference), are likely to represent a key aspect of many infectious processes, the nature of these interactions within mixed biofilm communities is poorly understood. We use in vitro biofilm models […]
Biofilm Volatile Compounds
Bacteria produce and release into their headspace a wide variety of volatile secondary metabolites. However, While detection and quantification of these volatiles as attractive or repellent odors and aromas are of great interest in food and cosmetic […]
Biofilm formation on medical devices is associated with hospital-acquired (nosocomial) infections. Due to biofilms’ high tolerance to antibiotics, classical treatments lack efficacy, and removal of the biofilm-contaminated device is often the only therapeutic option. […]
We designed a continuous-flow culture system in which biofilm formation can be reproducibly monitored and controlled in microfermentors handled at flow-rates avoiding accumulation of planktonic bacteria. This model is suited for biofilm macroscopic analysis, […]
2021Mining zebrafish microbiota reveals key community-level resistance against fish pathogen infection., ISME J 2021 03; 15(3): 702-719.
2021Gnotobiotic rainbow trout (Oncorhynchus mykiss) model reveals endogenous bacteria that protect against Flavobacterium columnare infection., PLoS Pathog 2021 01; 17(1): e1009302.
2017YeeJ is an inverse autotransporter from Escherichia coli that binds to peptidoglycan and promotes biofilm formation, Sci Rep. 2017 Sep 12;7(1):11326. doi: 10.1038/s41598-017-10902-0..
2017Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli, PLoS Genetics, May 19;13(5):e1006800.
2017Biological and chemical strategies for exploring inter- and intrakingdom communication mediated via bacterial volatile signals., Nat. Protoc. Jul;12(7):1359-1377.
2015Airborne bacterial interactions: Functions out of thin air?, Front. Microbiol. Dec. 2015;6:1476..
2014Aerial exposure to the bacterial volatile compound trimethylamine modifies antibiotic resistance of physically separated bacteria by raising culture medium pH, MBio 2014;5(1):e00944-13.