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© Research
Publication : Science Advances

Bacterial crystalline cellulose secretion via a supramolecular BcsHD scaffold

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science Advances - 16 Dec 2022

Wiem Abidi, Marion Decossas, Lucía Torres-Sánchez, Lucie Puygrenier, Sylvie Létoffé, Jean-Marc Ghigo, Petya V Krasteva

Link to Pubmed [PMID] – 36525496

Link to DOI – 10.1126/sciadv.add1170

Sci Adv. 2022 Dec 16;8(50):eadd1170.

Cellulose, the most abundant biopolymer on Earth, is not only the predominant constituent of plants but also a key extracellular polysaccharide in the biofilms of many bacterial species. Depending on the producers, chemical modifications, and three-dimensional assemblies, bacterial cellulose (BC) can present diverse degrees of crystallinity. Highly ordered, or crystalline, cellulose presents great economical relevance due to its ever-growing number of biotechnological applications. Even if some acetic acid bacteria have long been identified as BC superproducers, the molecular mechanisms determining the secretion of crystalline versus amorphous cellulose remain largely unknown. Here, we present structural and mechanistic insights into the role of the accessory subunits BcsH (CcpAx) and BcsD (CesD) that determine crystalline BC secretion in the Gluconacetobacter lineage. We show that oligomeric BcsH drives the assembly of BcsD into a supramolecular cytoskeletal scaffold that likely stabilizes the cellulose-extruding synthase nanoarrays through an unexpected inside-out mechanism for secretion system assembly.

https://pubmed.ncbi.nlm.nih.gov/36525496/