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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 25 Jun 2020

Quereda JJ, Morel C, Lopez-Montero N, Ziveri J, Rolland S, Grenier T, Aulner N, Danckaert A, Charbit A, Enninga J, Cossart P, Pizarro-Cerdá J,

Link to Pubmed [PMID] – 32582947

Link to DOI – jiaa36710.1093/infdis/jiaa367

J. Infect. Dis. 2020 Jun; ():

The bacterial pathogen Listeria monocytogenes (Lm) invades host cells, ruptures its internalization vacuole and reaches the cytosol for replication. A high-content siRNA microscopy screen allowed us to identify epithelial cell factors involved in Lm vacuolar rupture, among them the serine/threonine kinase Taok2. Kinase activity inhibition using a specific drug validated a role for Taok2 in favoring Lm cytoplasmic access. Furthermore, we showed that Taok2 recruitment to Lm vacuoles requires the presence of pore-forming toxin listeriolysin O. Overall, our study identifies the first set of host factors modulating Lm vacuolar rupture and cytoplasmic access in epithelial cells.

https://pubmed.ncbi.nlm.nih.gov/32582947