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Viral Pathogenesis Unit’s Project
Lisa Chakrabarti (PI)
Research in the Viral Pathogenesis Unit focuses on (i) the pharmacological, biological, and physiopathological study of chemokines and chemoreceptors, with an emphasis on CXCR4 and CCR5, the two major coreceptors for HIV entry; (ii) […]
2018CCR5 structural plasticity shapes HIV-1 phenotypic properties, PLoS Pathog. 2018 Dec;14(12):e1007432.
2018CCR5 Revisited: How Mechanisms of HIV Entry Govern AIDS Pathogenesis, J. Mol. Biol. 2018 Aug;430(17):2557-2589.
2018CCR5 adopts three homodimeric conformations that control cell surface delivery, Sci Signal 2018 05;11(529).
2014Targeting spare CC chemokine receptor 5 (CCR5) as a principle to inhibit HIV-1 entry, J. Biol. Chem. 2014 Jul;289(27):19042-52.
2013HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines, Proc. Natl. Acad. Sci. U.S.A. 2013 Jun;110(23):9475-80.
2007Identification of a postendocytic sorting sequence in CCR5, Mol. Pharmacol. 2007 Dec;72(6):1497-507.
2005On the dimerization of CCR5, Nat. Immunol. 2005 Jun;6(6):535; author reply 535-6.
2004Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation, J. Biol. Chem. 2005 Feb;280(8):6692-700.
2004The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis, Mol. Pharmacol. 2005 Jan;67(1):288-97.
2001Antigenically distinct conformations of CXCR4, J. Virol. 2001 Oct;75(19):8957-67.
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