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© Institut Pasteur
Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.

About

Rabies is an acute, progressive and incurable viral encephalitis, although some preventive measures were described by Louis Pasteur almost 130 years ago. This anthropozoonosis affects many different animal species and has an epidemiology that changes with time. The global incidence is estimated to be 50-60,000 cases in humans annually, and approximately 30 million people per year receive post-exposure prophylaxis (PEP) after a potentially infective bite. Most deaths from rabies occur in countries with inadequate public health resources, limited access to PEP, weak rabies surveillance and lack of One Health approach to control rabies in animals and consequently in humans. The resulting lack of robust data prevents the application of guided interventions that benefit populations, a strategy known as precision public health.

The overall strategy of the Unit is to address innovative and pertinent scientific questions related to rabies and other related infectious diseases that target the central nervous system. In response to the complexity of the mechanisms involved and of the questions addressed, this is achieved through the integration of many different approaches and competences present in the laboratory and developed through collaborations with relevant partners in other research laboratories located in France and abroad especially with the Institut Pasteur International Network.

More specifically, our aims are:

 

 

  • to develop new approaches for antiviral strategies and rabies post-exposure prophylaxis in humans, through a strong collaboration between the academic and the private sector. (Precision Public Health and One health).

 

Our research program is intimately connected with public health problems of interest for the National Reference Centre for Rabies (NCR-Rabies) and for the World Health Organization Collaborative Center for Research and Reference for Rabies (WHOCC-Rabies), both housed in the unit.

Our unit is also deeply involved in training and teaching activities with the International Workshop on rabies control and elimination and the course on Biobanking.

We are also partner of the EVA-GLOBAL project in which our objective is to contribute to generate the largest accessible collection of human and animal viruses . EVA-GLOBAL constitutes a unique opportunity for Institut Pasteur to set up an International Biological Resource Centre, PIBNET. Focusing on virus strains in collaboration with the Institut Pasteur International Network. The aim of this centre will be to preserve collections of virus strains and the information linked to them in collaboration with the present biological resource centre of Institut Pasteur (CRBIP).

Former Members

2000
2000
Name
Position
2015
2020
Rachel Lavenir
Technician
2015
2020
Sophie Rogee
Post-Doc
2015
2020
Maliki Ankavay
Graduate Student
2015
2020
Kemdongarti Naissengar
Graduate Student
2015
2020
Anthony Lepelletier
Technician
2015
2020
Benoît Besson
PhD Student
2015
2020
Cécile Troupin
Post-doc
2015
2020
Célia Gouzerh
Technician
2015
2020
Valentine Maire
Graduate Student
2015
2020
Florian Sonthonnax
PhD Student
2015
2020
Emilie Bonnaud
Project Manager
2015
2020
Marion Gressier
Undergraduate Student
2015
2020
Solenn Gavaud
Undergraduate Student
2015
2020
Morgan Nadal
Undergraduate Student
2015
2020
Julie Degen
Undergraduate Student
2015
2020
Margot Dropy
Undergraduate Student

Projects

Transversal Project

Fundings

Publications

The list of publication of our unit illustrates how our research program is intimately connected with public health problems of interest for the National Reference Centre for Rabies (NCR-Rabies) and for the World Health Organization Collaborative Center for Research and Reference for Rabies (WHOCCRabies), both housed in the unit.

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Contact

Phone : +33.145688750 Address 25-28 Rue du Docteur Roux 75015, Paris France