The surface complexes of many enveloped viruses are perfect targets for therapeutic design. Our group combines structural biology, computational biology, biophysics and virology techniques to study viral surface complexes and develop antiviral therapies. We have a particular interest in understanding the mechanisms of entry of large DNA viruses (poxviruses and related viruses), in the mechanisms of action of antibodies that clear the infection, whether neutralising or not, and in using this knowledge to develop novel therapies.
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2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2., J Exp Med 2022 Jul; 219(7): .
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2022Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses., Sci Transl Med 2022 Mar; 14(636): eabl5399.
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2022Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies., Science 2022 Jan; 375(6576): 104-109.
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2022Editorial: Influence of Protein-Protein Interactions (PPIs) on the Outcome of Viral Infections., Front Microbiol 2022 ; 13(): 943379.
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2021The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses., Cell 2021 Dec; 184(25): 6052-6066.e18.
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2021The Viral Class II Membrane Fusion Machinery: Divergent Evolution from an Ancestral Heterodimer., Viruses 2021 Nov; 13(12): .
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2021The surface glycoproteins of hantaviruses., Curr Opin Virol 2021 Oct; 50(): 87-94.
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2021Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling., PLoS Biol 2021 Sep; 19(9): e3001392.
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2021Generation of plasma cells and CD27-IgD- B cells during hantavirus infection is associated with distinct pathological findings., Clin Transl Immunology 2021 ; 10(7): e1313.
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2020The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism., Cell 2020 Oct; 183(2): 442-456.e16.
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