© Institut Pasteur
Phlébotome. Petit diptère de la famille des psychodidés (dans l'Ancien Monde). La femelle hématophage peut être vectrice entre autres de leishmaniose qu'elle transmet par piqûre à un vertébré, chien (hôte principal réservoir), homme ou encore rat (hôtes occasionnels).
Laboratory

Viruses and RNA Interference

About

 

We are witnessing an alarming increase in deadly virus transmission from mosquitoes to humans. For example, it is predicted that about half the population of the world is now at risk for diseases such as Dengue Fever. Research in our lab aims to understand the virus-insect relationship in order to control this emerging threat.

Insects have an immune system that allows them to live undisturbed when they are infected with a virus that is deadly to human beings. Why is this and how does this immune system work? Could we manipulate this immune system and therefore prevent humans from getting infected by insect bites? We aim to answer these questions, by using the fruit fly Drosophila melanogaster as a model insect to explore our research.

WHY IS THE MOSQUITO PROBLEM GETTING WORSE?

Urbanization has created a breeding ground for mosquitoes. Mosquitoes are being dispersed geographically due to increased travel, and to human-created ecological niches such as discarded rubber tires. We need to control mosquitoes in order to reduce the transmission of disease from mosquitoes to humans.

WHY NOT JUST ELIMINATE INSECTS ALTOGETHER?

Insects are the most extensive and diverse group of animals on earth and they represent more than half of all known living organisms. Insects are an essential part of the earth ecosystem, with many roles such as soil turning and aeration, dung burial, pest control, pollination and wildlife nutrition. We need them.

HOW CAN ONE CONTROL THE TRANSMISSION OF VIRUSES FROM INSECTS TO HUMANS?

Our hypothesis is that one might be able to control the transmission by understanding the relationship between the virus and the insect immune system. Why is it that an insect does not get sick when it is infected by a virus that kills humans? Can we remodel this insect immunity to protect humans from devastating insect-borne viral diseases?.

For more information, please visit our lab webpage.

 

Projects

Fundings

  • Cnrs-Q
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  • Ile de France
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  • Logo Investissements_d'avenir
  • axa-research-fund-logos-400x99
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Publications

Contact

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Address
25-28 Rue du Docteur Roux
75015, Paris
France